A Proinflammatory Stimulus Disrupts Hippocampal Plasticity and Learning via Microglial Activation and 25-Hydroxycholesterol. Izumi Y, Cashikar AG, Krishnan K, Paul SM, Covey DF, Mennerick SJ, Zorumski CF. J Neurosci. 2021 Dec 8;41(49):10054-10064.

Neurosteroid modulation of GABAA receptor function by independent action at multiple specific binding sites. Wang L, Covey DF, Akk G, Evers AS. Curr Neuropharmacol. 2021 Dec 2. 

Evaluation of Discipline-Specific Outcomes Through a Multidisciplinary Team Clinic for Patients With Isolated Cleft Palate. Trivedi PB, Padovano WM, Skolnick GB, Menezes MD, Grames LM, Cheung S, Kim AM, Cradock MM, Naidoo SD, Snyder-Warwick AK, Patel KB. Cleft Palate Craniofac J. 2021 Dec;58(12):1517-1525.

The zebrafish issue: 25 years on. Mullins MC, Navajas Acedo J, Priya R, Solnica-Krezel L, Wilson SW. Development. 2021 Dec 15;148(24):dev200343. 

Regenerative responses of rabbit corneal endothelial cells to stimulation by fibroblast growth factor 1 (FGF1) derivatives, TTHX1001 and TTHX1114. Weant J, Eveleth DD, Subramaniam A, Jenkins-Eveleth J, Blaber M, Li L, Ornitz DM, Alimardanov A, Broadt T, Dong H, Vyas V, Yang X, Bradshaw RA. Growth Factors. 2021 Dec 9:1-14. 

Hedgehog-Interacting Protein is a multimodal antagonist of Hedgehog signaling. Griffiths SC, Schwab RA, El Omari K, Bishop B, Iverson EJ, Malinauskas T, Dubey R, Qian M, Covey DF, Gilbert RJC, Rohatgi R, Siebold C. Nat Commun. 2021 Dec 9;12(1):7171.

Nanomolar, Noncovalent Antagonism of Hedgehog Cholesterolysis: Exception to the “Irreversibility Rule” for Protein Autoprocessing Inhibition. Wagner AG, Stagnitta RT, Xu Z, Pezzullo JL, Kandel N, Giner JL, Covey DF, Wang C, Callahan BP. Biochemistry. 2021 Dec 23.

 Zinc is an intracellular signal during sperm activation in Caenorhabditis elegans. Tan CH, Kornfeld K. Development. 2021 Nov 1;148(21):dev199836. 

Live imaging reveals the cellular events downstream of SARM1 activation. Ko KW, Devault L, Sasaki Y, Milbrandt J, DiAntonio A. Elife. 2021 Nov 15;10:e71148.

Assessment of Swim Endurance and Swim Behavior in Adult Zebrafish. Burris B, Jensen N, Mokalled MH. J Vis Exp. 2021 Nov 12;(177). 

Understanding Circadian Mechanisms of Sudden Cardiac Death: A Report From the National Heart, Lung, and Blood Institute Workshop, Part 2: Population and Clinical Considerations. Delisle BP, George AL Jr, Nerbonne JM, Bass JT, Ripplinger CM, Jain MK, Hermanstyne TO, Young ME, Kannankeril PJ, Duffy JF, Goldhaber JI, Hall MH, Somers VK, Smolensky MH, Garnett CE, Anafi RC, Scheer FAJL, Shivkumar K, Shea SA, Balijepalli RC. Circ Arrhythm Electrophysiol. 2021 Nov;14(11):e010190.

Neurotoxins subvert the allosteric activation mechanism of SARM1 to induce neuronal loss. Wu T, Zhu J, Strickland A, Ko KW, Sasaki Y, Dingwall CB, Yamada Y, Figley MD, Mao X, Neiner A, Bloom AJ, DiAntonio A, Milbrandt J. Cell Rep. 2021 Oct 19;37(3):109872.

Cadmium hijacks the high zinc response by binding and activating the HIZR-1 nuclear receptor. Earley BJ, Cubillas C, Warnhoff K, Ahmad R, Alcantar A, Lyon MD, Schneider DL, Kornfeld K. Proc Natl Acad Sci U S A. 2021 Oct 19;118(42):e2022649118. 

Brief Electrical Stimulation Accelerates Axon Regeneration and Promotes Recovery Following Nerve Transection and Repair in Mice. Sayanagi J, Acevedo-Cintrón JA, Pan D, Schellhardt L, Hunter DA, Snyder-Warwick AK, Mackinnon SE, Wood MD. J Bone Joint Surg Am. 2021 Oct 20;103(20):e80.

Cardiac radiotherapy induces electrical conduction reprogramming in the absence of transmural fibrosis. Zhang DM, Navara R, Yin T, Szymanski J, Goldsztejn U, Kenkel C, Lang A, Mpoy C, Lipovsky CE, Qiao Y, Hicks S, Li G, Moore KMS, Bergom C, Rogers BE, Robinson CG, Cuculich PS, Schwarz JK, Rentschler SL. Nat Commun. 2021 Sep 24;12(1):5558.

CARMIL3 is important for cell migration and morphogenesis during early development in zebrafish. Stark BC, Gao Y, Sepich DS, Belk L, Culver MA, Hu B, Mekel M, Ferris W, Shin J, Solnica-Krezel L, Lin F, Cooper JA. Dev Biol. 2021 Sep 29:S0012-1606(21)00215-3. 

Validation of Trifluoromethylphenyl Diazirine Cholesterol Analogues As Cholesterol Mimetics and Photolabeling Reagents. Krishnan K, Qian M, Feltes M, Chen ZW, Gale S, Wang L, Sugasawa Y, Reichert DE, Schaffer JE, Ory DS, Evers AS, Covey DF. ACS Chem Biol. 2021 Aug 20;16(8):1493-1507. 

Identification of structures for ion channel kinetic models. Mangold KE, Wang W, Johnson EK, Bhagavan D, Moreno JD, Nerbonne JM, Silva JR. PLoS Comput Biol. 2021 Aug 16;17(8):e1008932.

OCT4 cooperates with distinct ATP-dependent chromatin remodelers in naïve and primed pluripotent states in human. Huang X, Park KM, Gontarz P, Zhang B, Pan J, McKenzie Z, Fischer LA, Dong C, Dietmann S, Xing X, Shliaha PV, Yang J, Li D, Ding J, Lungjangwa T, Mitalipova M, Khan SA, Imsoonthornruksa S, Jensen N, Wang T, Kadoch C, Jaenisch R, Wang J, Theunissen TW. Nat Commun. 2021 Aug 26;12(1):5123.

Epigenetic regulation during human cortical development: Seq-ing answers from the brain to the organoid. Lewis EMA, Kaushik K, Sandoval LA, Antony I, Dietmann S, Kroll KL. Neurochem Int. 2021 Jul;147:105039. 

T-box transcription factor 21 is expressed in terminal Schwann cells at the neuromuscular junction. Jablonka-Shariff A, Broberg C, Rios R, Snyder-Warwick AK. Muscle Nerve. 2021 Jul;64(1):109-115. 

ETV4 and ETV5 drive synovial sarcoma through cell cycle and DUX4 embryonic pathway control. DeSalvo J, Ban Y, Li L, Sun X, Jiang Z, Kerr DA, Khanlari M, Boulina M, Capecchi MR, Partanen JM, Chen L, Kondo T, Ornitz DM, Trent JC, Eid JE. J Clin Invest. 2021 Jul 1;131(13):e141908. 

Upregulation of FGF9 in Lung Adenocarcinoma Transdifferentiation to Small Cell Lung Cancer. shioka K, Yasuda H, Hamamoto J, Terai H, Emoto K, Kim TJ, Hirose S, Kamatani T, Mimaki S, Arai D, Ohgino K, Tani T, Masuzawa K, Manabe T, Shinozaki T, Mitsuishi A, Ebisudani T, Fukushima T, Ozaki M, Ikemura S, Kawada I, Naoki K, Nakamura M, Ohtsuka T, Asamura H, Tsuchihara K, Hayashi Y, Hegab AE, Kobayashi SS, Kohno T, Watanabe H, Ornitz DM, Betsuyaku T, Soejima K, Fukunaga K. Cancer Res. 2021 Jul 15;81(14):3916-3929.

Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women. Yoshino M, Yoshino J, Kayser BD, Patti GJ, Franczyk MP, Mills KF, Sindelar M, Pietka T, Patterson BW, Imai SI, Klein S. Science. 2021 Jun 11;372(6547):1224-1229.

Balancing serendipity and reproducibility: Pluripotent stem cells as experimental systems for intellectual and developmental disorders. Anderson NC, Chen PF, Meganathan K, Afshar Saber W, Petersen AJ, Bhattacharyya A, Kroll KL, Sahin M; Cross-IDDRC Human Stem Cell Working Group. Stem Cell Reports. 2021 Jun 8;16(6):1446-1457. 

MiR-124 synergism with ELAVL3 enhances target gene expression to promote neuronal maturity. Lu YL, Liu Y, McCoy MJ, Yoo AS. Proc Natl Acad Sci U S A. 2021 Jun 1;118(22):e2015454118. 

Postnatal expression profiles of atypical cadherin FAT1 suggest its role in autism. Frei JA, Brandenburg C, Nestor JE, Hodzic DM, Plachez C, McNeill H, Dykxhoorn DM, Nestor MW, Blatt GJ, Lin YC. Biol Open. 2021 Jun 15;10(6):bio056457.

Modulation of the effects of Class-Ib antiarrhythmics on cardiac NaV1.5-encoded channels by accessory NaVβ subunits. Zhu W, Wang W, Angsutararux P, Mellor RL, Isom LL, Nerbonne JM, Silva JR. JCI Insight. 2021 Jun 22:143092. 

Deletion of Fibroblast growth factor 9 globally and in skeletal muscle results in enlarged tuberosities at sites of deltoid tendon attachments. Leek CC, Soulas JM, Bhattacharya I, Ganji E, Locke RC, Smith MC, Bhavsar JD, Polson SW, Ornitz DM, Killian ML. Dev Dyn. 2021 Jun 6. doi: 10.1002/dvdy.383.

Probing the signaling requirements for naive human pluripotency by high-throughput chemical screening. Khan SA, Park KM, Fischer LA, Dong C, Lungjangwa T, Jimenez M, Casalena D, Chew B, Dietmann S, Auld DS, Jaenisch R, Theunissen TW. Cell Rep. 2021 Jun 15;35(11):109233.

Mechanical dysfunction of the sarcomere induced by a pathogenic mutation in troponin T drives cellular adaptation. Clippinger SR, Cloonan PE, Wang W, Greenberg L, Stump WT, Angsutararux P, Nerbonne JM, Greenberg MJ. J Gen Physiol. 2021 May 3;153(5):e202012787.

Gene expression dynamics underlying cell fate emergence in 2D micropatterned human embryonic stem cell gastruloids. Minn KT, Dietmann S, Waye SE, Morris SA, Solnica-Krezel L. Stem Cell Reports. 2021 May 11;16(5):1210-1227.

Differential effects of the novel neurosteroid hypnotic (3β,5β,17β)-3-hydroxyandrostane-17-carbonitrile on electroencephalogram activity in male and female rats. Joksimovic SM, Sampath D, Krishnan K, Covey DF, Jevtovic-Todorovic V, Raol YH, Todorovic SM. Br J Anaesth. 2021 May 7:S0007-0912(21)00218-X.

Molecular, Cellular and Functional Changes in the Retinas of Young Adult Mice Lacking the Voltage-Gated K+ Channel Subunits Kv8.2 and K2.1. Jiang X, Rashwan R, Voigt V, Nerbonne J, Hunt DM, Carvalho LS. Int J Mol Sci. 2021 May 5;22(9):4877.

A genetic screen for regulators of muscle morphogenesis in Drosophila. Ou T, Huang G, Wilson B, Gontarz P, Skeath JB, Johnson AN. G3 (Bethesda). 2021 May 16:jkab172.

Model organisms contribute to diagnosis and discovery in the undiagnosed diseases network: current state and a future vision. Baldridge D, Wangler MF, Bowman AN, Yamamoto S; Undiagnosed Diseases Network, Schedl T, Pak SC, Postlethwait JH, Shin J, Solnica-Krezel L, Bellen HJ, Westerfield M. Orphanet J Rare Dis. 2021 May 7;16(1):206.

SARM1 is a metabolic sensor activated by an increased NMN/NAD+ ratio to trigger axon degeneration. Figley MD, Gu W, Nanson JD, Shi Y, Sasaki Y, Cunnea K, Malde AK, Jia X, Luo Z, Saikot FK, Mosaiab T, Masic V, Holt S, Hartley-Tassell L, McGuinness HY, Manik MK, Bosanac T, Landsberg MJ, Kerry PS, Mobli M, Hughes RO, Milbrandt J, Kobe B, DiAntonio A, Ve T. Neuron. 2021 Apr 7;109(7):1118-1136.e11.

Mind the Gap: Alveolar Bone Graft Revision in the Era of Computed Tomography. Zubovic E, Skolnick GB, Said AM, Nissen RJ, Snyder-Warwick AK, Patel KB. Cleft Palate Craniofac J. 2021 Apr 1:10556656211002689.

Presurgical Orthopedic Intervention Prior to Cleft Lip and Palate Repair: Nasoalveolar Molding Versus Passive Molding Appliance Therapy. Gibson E, Pfeifauf KD, Skolnick GB, Kim A, Naidoo SD, Snyder-Warwick A, Huebener DV, Patel KB. J Craniofac Surg. 2021 Mar-Apr 01;32(2):486-491.

Quantitative imaging of membrane contact sites for sterol transfer between endo-lysosomes and mitochondria in living cells. Juhl AD, Heegaard CW, Werner S, Schneider G, Krishnan K, Covey DF, Wüstner D. Sci Rep. 2021 Apr 26;11(1):8927.

Family-Centered Pediatric Plastic Surgery Care. Patel KB, Pfeifauf KD, Snyder-Warwick A. Mo Med. 2021 Mar-Apr;118(2):124-129.

Long-Term Effects of Nasoalveolar Molding in Patients With Unilateral Cleft Lip and Palate: A Systematic Review and Meta-Analysis. Padovano WM, Skolnick GB, Naidoo SD, Snyder-Warwick AK, Patel KB. Cleft Palate Craniofac J. 2021 Apr 22:10556656211009702.

NAD+ oscillation and hypothalamic neuronal functions. Tokizane K, Imai SI. Fac Rev. 2021 Apr 27;10:42.

Bidirectional regulation of glial potassium buffering – glioprotection versus neuroprotection. Li H, Lones L, DiAntonio A. Elife. 2021 Mar 1;10:e62606.

Women in Leadership and Their Influence on the Gender Diversity of Academic Plastic Surgery Programs. Keane AM, Larson EL, Santosa KB, Vannucci B, Waljee JF, Tenenbaum MM, Mackinnon SE, Snyder-Warwick AK. Plast Reconstr Surg. 2021 Mar 1;147(3):516-526.

Localized EMT reprograms glial progenitors to promote spinal cord repair. Klatt Shaw D, Saraswathy VM, Zhou L, McAdow AR, Burris B, Butka E, Morris SA, Dietmann S, Mokalled MH. Dev Cell. 2021 Mar 8;56(5):613-626.e7.

The cartilage matrisome in adolescent idiopathic scoliosis. Wise CA, Sepich D, Ushiki A, Khanshour AM, Kidane YH, Makki N, Gurnett CA, Gray RS, Rios JJ, Ahituv N, Solnica-Krezel L. Bone Res. 2020 Mar 9;8(1):13.

Efficient CRISPR/Cas9 mutagenesis for neurobehavioral screening in adult zebrafish. Klatt Shaw D, Mokalled MH. G3 (Bethesda). 2021 Mar 20:jkab089.

Postembryonic screen for mutations affecting spine development in zebrafish. Gray RS, Gonzalez R, Ackerman SD, Minowa R, Griest JF, Bayrak MN, Troutwine B, Canter S, Monk KR, Sepich DS, Solnica-Krezel L. Dev Biol. 2021 Mar;471:18-33. 

Deeply-supervised density regression for automatic cell counting in microscopy images. He S, Minn KT, Solnica-Krezel L, Anastasio MA, Li H. Med Image Anal. 2021 Feb;68:101892. 

Evaluation of Discipline-Specific Outcomes Through a Multidisciplinary Team Clinic for Patients With Isolated Cleft Palate. Trivedi PB, Padovano WM, Skolnick GB, Menezes MD, Grames LM, Cheung S, Kim AM, Cradock MM, Naidoo SD, Snyder-Warwick AK, Patel KB. Cleft Palate Craniofac J. 2021 Feb 4:1055665621990174.

Proteomic and functional mapping of cardiac NaV1.5 channel phosphorylation sites. Lorenzini M, Burel S, Lesage A, Wagner E, Charrière C, Chevillard PM, Evrard B, Maloney D, Ruff KM, Pappu RV, Wagner S, Nerbonne JM, Silva JR, Townsend RR, Maier LS, Marionneau C. J Gen Physiol. 2021 Feb 1;153(2):e202012646. 

Global, cell non-autonomous gene regulation drives individual lifespan among isogenic C. elegans. Kinser HE, Mosley MC, Plutzer IB, Pincus Z. Elife. 2021 Feb 1;10:e65026.

Using an Intake Form and Clinic Dashboard to Tailor and Improve the Cleft Team Clinic Visit for Families. Pfeifauf KD, Snyder-Warwick AK, Scheve S, Grellner CL, Skolnick GB, Naidoo SD, Patel KB. Cleft Palate Craniofac J. 2021 Jan;58(1):114-117. 

Macrophage roles in peripheral nervous system injury and pathology: Allies in neuromuscular junction recovery. Rios R, Jablonka-Shariff A, Broberg C, Snyder-Warwick AK. Mol Cell Neurosci. 2021 Jan 8;111:103590.

Small Molecule SARM1 Inhibitors Recapitulate the SARM1-/- Phenotype and Allow Recovery of a Metastable Pool of Axons Fated to Degenerate. Hughes RO, Bosanac T, Mao X, Engber TM, DiAntonio A, Milbrandt J, Devraj R, Krauss R. Cell Rep. 2021 Jan 5;34(1):108588. 

Multiple domain interfaces mediate SARM1 autoinhibition. Shen C, Vohra M, Zhang P, Mao X, Figley MD, Zhu J, Sasaki Y, Wu H, DiAntonio A, Milbrandt J. Proc Natl Acad Sci U S A. 2021 Jan 26;118(4):e2023151118.