Orsay Virus Infection of Caenorhabditis elegans Is Modulated by Zinc and Dependent on Lipids. Casorla-Perez LA, Guennoun R, Cubillas C, Peng B, Kornfeld K, Wang D. J Virol. 2022 Nov 23;96(22):e0121122.

FGFR2b signalling restricts lineage-flexible alveolar progenitors during mouse lung development and converges in mature alveolar type 2 cells. Jones MR, Lingampally A, Ahmadvand N, Chong L, Wu J, Wilhem J, Vazquez-Armendariz AI, Ansari M, Herold S, Ornitz DM, Schiller HB, Chao CM, Zhang JS, Carraro G, Bellusci S. Cell Mol Life Sci. 2022 Nov 29;79(12):609.

Duplication Versus Deletion Through the Lens of 15q13.3: Clinical and Research Implications of Studying Copy Number Variants Associated with Neuropsychiatric Disorders in Induced Pluripotent Stem Cell-Derived Neurons. Antony I, Narasimhan M, Shen R, Prakasam R, Kaushik K, Chapman G, Kroll KL. Stem Cell Rev Rep. 2022 Nov 12.

Myostatin is a negative regulator of adult neurogenesis after spinal cord injury in zebrafish. Saraswathy VM, Zhou L, McAdow AR, Burris B, Dogra D, Reischauer S, Mokalled MH. Cell Rep. 2022 Nov 22;41(8):111705.

Guidelines for assessment of cardiac electrophysiology and arrhythmias in small animals. Ripplinger CM, Glukhov AV, Kay MW, Boukens BJ, Chiamvimonvat N, Delisle BP, Fabritz L, Hund TJ, Knollmann BC, Li N, Murray KT, Poelzing S, Quinn TA, Remme CA, Rentschler SL, Rose RA, Posnack NG. Am J Physiol Heart Circ Physiol. 2022 Dec 1;323(6):H1137-H1166. doi: 10.1152/ajpheart.00439.2022. Epub 2022 Oct 21.

Can the “female protective effect” liability threshold model explain sex differences in autism spectrum disorder? Dougherty JD, Marrus N, Maloney SE, Yip B, Sandin S, Turner TN, Selmanovic D, Kroll KL, Gutmann DH, Constantino JN, Weiss LA. Neuron. 2022 Oct 19;110(20):3243-3262.

The inner nuclear membrane protein NEMP1 supports nuclear envelope openings and enucleation of erythroblasts. Hodzic D, Wu J, Krchma K, Jurisicova A, Tsatskis Y, Liu Y, Ji P, Choi K, McNeill H. PLoS Biol. 2022 Oct 10;20(10):e3001811.

An iPS-derived in vitro model of human atrial conduction. Biendarra-Tiegs SM, Yechikov S, Shergill B, Brumback B, Takahashi K, Shirure VS, Gonzalez RE, Houshmand L, Zhong D, Weng KC, Silva J, Smith TW, Rentschler SL, George SC. Physiol Rep. 2022 Sep;10(18):e15407.

Human Cardiac Pericytes are Susceptible to SARS-CoV-2 Infection. Brumback BD, Dmytrenko O, Robinson AN, Bailey AL, Ma P, Liu J, Hicks SC, Ng S, Li G, Zhang DM, Lipovsky CE, Lin CY, Diamond MS, Lavine K, Rentschler SL. JACC Basic Transl Sci. 2022 Sep 14.

Regulation of human cortical interneuron development by the chromatin remodeling protein CHD2. Lewis EMA, Chapman G, Kaushik K, Determan J, Antony I, Meganathan K, Narasimhan M, Gontarz P, Zhang B, Kroll KL. Sci Rep. 2022 Sep 17;12(1):15636.

Control of aging by the renin-angiotensin system: a review of C. elegans, Drosophila, and mammals.  Egan BM, Scharf A, Pohl F, Kornfeld K. Front Pharmacol. 2022 Sep 14;13:938650.

Fibroblast growth factor receptor signaling in cardiomyocytes is protective in the acute phase following ischemia-reperfusion injury. Matsiukevich D, House SL, Weinheimer C, Kovacs A, Ornitz DM. Front Cardiovasc Med. 2022 Sep 23;9:1011167. 

Lysosomal GPCR-like protein LYCHOS signals cholesterol sufficiency to mTORC1. Shin HR, Citron YR, Wang L, Tribouillard L, Goul CS, Stipp R, Sugasawa Y, Jain A, Samson N, Lim CY, Davis OB, Castaneda-Carpio D, Qian M, Nomura DK, Perera RM, Park E, Covey DF, Laplante M, Evers AS, Zoncu R. Science. 2022 Sep 16;377(6612):1290-1298.

Cyclic ADP ribose isomers: Production, chemical structures, and immune signaling. Manik MK, Shi Y, Li S, Zaydman MA, Damaraju N, Eastman S, Smith TG, Gu W, Masic V, Mosaiab T, Weagley JS, Hancock SJ, Vasquez E, Hartley-Tassell L, Kargios N, Maruta N, Lim BYJ, Burdett H, Landsberg MJ, Schembri MA, Prokes I, Song L, Grant M, DiAntonio A, Nanson JD, Guo M, Milbrandt J, Ve T, Kobe B. Science. 2022 Sep 30;377(6614):eadc8969.

Defining hierarchical protein interaction networks from spectral analysis of bacterial proteomes. Zaydman MA, Little AS, Haro F, Aksianiuk V, Buchser WJ, DiAntonio A, Gordon JI, Milbrandt J, Raman AS. Elife. 2022 Aug 17;11:e74104.

Integrated multi-omic characterization of congenital heart disease. Integrated multi-omic characterization of congenital heart disease. Hill MC, Kadow ZA, Long H, Morikawa Y, Martin TJ, Birks EJ, Campbell KS, Nerbonne J, Lavine K, Wadhwa L, Wang J, Turaga D, Adachi I, Martin JF. Nature. 2022 Aug;608(7921):181-191.

Impact of a Palatal Fistula After Cleft Palate Repair on Velopharyngeal Closure. Geisman MM, Skolnick GB, Grames LM, Naidoo SD, Snyder-Warwick AK, Patel KB. Cleft Palate Craniofac J. 2022 Aug 1:10556656221116534.

New developments in the biology of fibroblast growth factors. Ornitz DM, Itoh N. WIREs Mech Dis. 2022 Jul;14(4):e1549.

Slc12a8 in the lateral hypothalamus maintains energy metabolism and skeletal muscle functions during aging. Ito N, Takatsu A, Ito H, Koike Y, Yoshioka K, Kamei Y, Imai SI. Cell Rep. 2022 Jul 26;40(4):111131. 

Can the “female protective effect” liability threshold model explain sex differences in autism spectrum disorder? Dougherty JD, Marrus N, Maloney SE, Yip B, Sandin S, Turner TN, Selmanovic D, Kroll KL, Gutmann DH, Constantino JN, Weiss LA. Neuron. 2022 Jul 20:S0896-6273(22)00589-X. 

Factors contributing to delay or absence of alveolar bone grafting. Pfeifauf KD, Cooper DC, Gibson E, Skolnick GB, Naidoo SD, Snyder-Warwick AK, Patel KB. Am J Orthod Dentofacial Orthop. 2022 Jun;161(6):820-828.e1.

A pathogenic mechanism associated with myopathies and structural birth defects involves TPM2-directed myogenesis. McAdow J, Yang S, Ou T, Huang G, Dobbs MB, Gurnett CA, Greenberg MJ, Johnson AN. JCI Insight. 2022 Jun 22;7(12):e152466. 

Fibroblast growth factor-9 expression in airway epithelial cells amplifies the type I interferon response and alters influenza A virus pathogenesis. Hiller BE, Yin Y, Perng YC, de Araujo Castro Í, Fox LE, Locke MC, Monte KJ, López CB, Ornitz DM, Lenschow DJ. PLoS Pathog. 2022 Jun 8;18(6):e1010228.

 Loss of Stathmin-2, a hallmark of TDP-43-associated ALS, causes motor neuropathy. Krus KL, Strickland A, Yamada Y, Devault L, Schmidt RE, Bloom AJ, Milbrandt J, DiAntonio A. Cell Rep. 2022 Jun 28;39(13):111001.

Distinct developmental and degenerative functions of SARM1 require NAD+ hydrolase activity. Brace EJ, Essuman K, Mao X, Palucki J, Sasaki Y, Milbrandt J, DiAntonio A. PLoS Genet. 2022 Jun 23;18(6):e1010246. 

Recapitulation of endogenous 4R tau expression and formation of insoluble tau in directly reprogrammed human neurons. Capano LS, Sato C, Ficulle E, Yu A, Horie K, Kwon JS, Burbach KF, Barthélemy NR, Fox SG, Karch CM, Bateman RJ, Houlden H, Morimoto RI, Holtzman DM, Duff KE, Yoo AS. Cell Stem Cell. 2022 Jun 2;29(6):918-932.e8.

Patched 1 regulates Smoothened by controlling sterol binding to its extracellular cysteine-rich domain. Kinnebrew M, Woolley RE, Ansell TB, Byrne EFX, Frigui S, Luchetti G, Sircar R, Nachtergaele S, Mydock-McGrane L, Krishnan K, Newstead S, Sansom MSP, Covey DF, Siebold C, Rohatgi R. Sci Adv. 2022 Jun 3;8(22):eabm5563.

Nanomolar, Noncovalent Antagonism of Hedgehog Cholesterolysis: Exception to the “Irreversibility Rule” for Protein Autoprocessing Inhibition. Wagner AG, Stagnitta RT, Xu Z, Pezzullo JL, Kandel N, Giner JL, Covey DF, Wang C, Callahan BP. Biochemistry. 2022 Jun 7;61(11):1022-1028. 

Integrated multiomic characterization of congenital heart disease. Hill MC, Kadow ZA, Long H, Morikawa Y, Martin TJ, Birks EJ, Campbell KS, Nerbonne J, Lavine K, Wadhwa L, Wang J, Turaga D, Adachi I, Martin JF. Nature. 2022 Jun 22. 

Structural basis of SARM1 activation, substrate recognition, and inhibition by small molecules. Shi Y, Kerry PS, Nanson JD, Bosanac T, Sasaki Y, Krauss R, Saikot FK, Adams SE, Mosaiab T, Masic V, Mao X, Rose F, Vasquez E, Furrer M, Cunnea K, Brearley A, Gu W, Luo Z, Brillault L, Landsberg MJ, DiAntonio A, Kobe B, Milbrandt J, Hughes RO, Ve T. Mol Cell. 2022 May 5;82(9):1643-1659.e10.

The H3K27M mutation alters stem cell growth, epigenetic regulation, and differentiation potential. Kfoury-Beaumont N, Prakasam R, Pondugula S, Lagas JS, Matkovich S, Gontarz P, Yang L, Yano H, Kim AH, Rubin JB, Kroll KL. BMC Biol. 2022 May 30;20(1):124.

A genome-wide CRISPR-Cas9 knockout screen identifies essential and growth-restricting genes in human trophoblast stem cells. Dong C, Fu S, Karvas RM, Chew B, Fischer LA, Xing X, Harrison JK, Popli P, Kommagani R, Wang T, Zhang B, Theunissen TW. Nat Commun. 2022 May 10;13(1):2548.

Stem-cell-derived trophoblast organoids model human placental development and susceptibility to emerging pathogens. Karvas RM, Khan SA, Verma S, Yin Y, Kulkarni D, Dong C, Park KM, Chew B, Sane E, Fischer LA, Kumar D, Ma L, Boon ACM, Dietmann S, Mysorekar IU, Theunissen TW. Cell Stem Cell. 2022 May 5;29(5):810-825.e8.

Further Evidence that Inhibition of Neuronal Voltage-Gated Calcium Channels Contributes to the Hypnotic Effect of Neurosteroid Analogue, 3β-OH. Timic Stamenic T, Manzella FM, Maksimovic S, Krishnan K, Covey DF, Jevtovic-Todorovic V, Todorovic SM. Front Pharmacol. 2022 May 23;13:850658.

Identification of a retinoic acid-dependent haemogenic endothelial progenitor from human pluripotent stem cells. Luff SA, Creamer JP, Valsoni S, Dege C, Scarfò R, Dacunto A, Cascione S, Randolph LN, Cavalca E, Merelli I, Morris SA, Ditadi A, Sturgeon CM. Nat Cell Biol. 2022 Apr 28. doi: 10.1038/s41556-022-00898-9.

Age-related disruption of the proteome and acetylome in mouse hearts is associated with loss of function and attenuated by elamipretide (SS-31) and nicotinamide mononucleotide (NMN) treatment. Whitson JA, Johnson R, Wang L, Bammler TK, Imai SI, Zhang H, Fredrickson J, Latorre-Esteves E, Bitto A, MacCoss MJ, Rabinovitch PS. Geroscience. 2022 Apr 13. doi: 10.1007/s11357-022-00564-w.

Products of gut microbial Toll/interleukin-1 receptor domain NADase activities in gnotobiotic mice and Bangladeshi children with malnutrition. Weagley JS, Zaydman M, Venkatesh S, Sasaki Y, Damaraju N, Yenkin A, Buchser W, Rodionov DA, Osterman A, Ahmed T, Barratt MJ, DiAntonio A, Milbrandt J, Gordon JI. Cell Rep. 2022 Apr 26;39(4):110738.

Long-Term Effects of Nasoalveolar Molding in Patients With Unilateral Cleft Lip and Palate: A Systematic Review and Meta-Analysis. Padovano WM, Skolnick GB, Naidoo SD, Snyder-Warwick AK, Patel KB. Cleft Palate Craniofac J. 2022 Apr;59(4):462-474.

Short-Duration, Pulsatile, Electrical Stimulation Therapy Accelerates Axon Regeneration and Recovery following Tibial Nerve Injury and Repair in Rats. Roh J, Schellhardt L, Keane GC, Hunter DA, Moore AM, Snyder-Warwick AK, Mackinnon SE, Wood MD. Plast Reconstr Surg. 2022 Apr 1;149(4):681e-690e.

Capybara: A computational tool to measure cell identity and fate transitions. Kong W, Fu YC, Holloway EM, Garipler G, Yang X, Mazzoni EO, Morris SA. Cell Stem Cell. 2022 Apr 7;29(4):635-649.e11

The Enantiomer of Allopregnanolone Prevents Pressure-Mediated Retinal Degeneration Via Autophagy. Ishikawa M, Nakazawa T, Kunikata H, Sato K, Yoshitomi T, Krishnan K, Covey DF, Zorumski CF, Izumi Y. Front Pharmacol. 2022 Mar 16;13:855779.

FK506-binding protein-like and FK506-binding protein 8 regulate dual leucine zipper kinase degradation and neuronal responses to axon injury. Lee B, Oh Y, Cho E, DiAntonio A, Cavalli V, Shin JE, Choi HW, Cho Y.J Biol Chem. 2022 Mar;298(3):101647.

Synthetic neuroactive steroids as new sedatives and anaesthetics: Back to the future. Manzella FM, Covey DF, Jevtovic-Todorovic V, Todorovic SM. J Neuroendocrinol. 2022 Feb;34(2):e13086.

Sarm1 activation produces cADPR to increase intra-axonal Ca++ and promote axon degeneration in PIPN. Li Y, Pazyra-Murphy MF, Avizonis D, de Sá Tavares Russo M, Tang S, Chen CY, Hsueh YP, Bergholz JS, Jiang T, Zhao JJ, Zhu J, Ko KW, Milbrandt J, DiAntonio A, Segal RA. J Cell Biol. 2022 Feb 7;221(2):e202106080.

Spatiotemporal expression of regulatory kinases directs the transition from mitosis to cellular morphogenesis in Drosophila. Yang S, McAdow J, Du Y, Trigg J, Taghert PH, Johnson AN. Nat Commun. 2022 Feb 9;13(1):772.

A phytobacterial TIR domain effector manipulates NAD+ to promote virulence. Eastman S, Smith T, Zaydman MA, Kim P, Martinez S, Damaraju N, DiAntonio A, Milbrandt J, Clemente TE, Alfano JR, Guo M. New Phytol. 2022 Jan;233(2):890-904.

IL-4 expressing cells are recruited to nerve after injury and promote regeneration. Pan D, Schellhardt L, Acevedo-Cintron JA, Hunter D, Snyder-Warwick AK, Mackinnon SE, Wood MD. Exp Neurol. 2022 Jan;347:113909.

Protein phosphatase 2A restrains DLK signaling to promote proper Drosophila synaptic development and mammalian cortical neuron survival. Hayne M, DiAntonio A. Hayne M, DiAntonio A. Neurobiol Dis. 2022 Feb;163:105586.

Intrinsic mechanisms in the gating of resurgent Na+ currents. Ransdell JL, Moreno JD PhD, Bhagavan D, Silva JR, Nerbonne JM. Elife. 2022 Jan 25;11:e70173.

Constitutively active SARM1 variants that induce neuropathy are enriched in ALS patients. Bloom AJ, Mao X, Strickland A, Sasaki Y, Milbrandt J, DiAntonio A.
Mol Neurodegener. 2022 Jan 6;17(1):1.

Generating Trophoblast Stem Cells from Human Naïve Pluripotent Stem Cells. Dong C, Theunissen TW. Methods Mol Biol. 2022;2416:91-104.

Constitutively active SARM1 variants that induce neuropathy are enriched in ALS patients. Bloom AJ, Mao X, Strickland A, Sasaki Y, Milbrandt J, DiAntonio A.
Mol Neurodegener. 2022 Jan 6;17(1):1.

Polyunsaturated fatty acids inhibit a pentameric ligand-gated ion channel through one of two binding sites. Dietzen NM, Arcario MJ, Chen LJ, Petroff JT 2nd, Moreland KT, Krishnan K, Brannigan G, Covey DF, Cheng WW. Elife. 2022 Jan 4;11:e74306.