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2025 Publications

  • Easily adaptable Fiji macro for mean linear intercept measurement of peripheral respiratory airspace. Patlin B, Yin Y, Li L, Ornitz DM. Dev Dyn. 2025 Sep 12. doi: 10.1002/dvdy.70078. PMID: 40937540
  • Control of sensory cell differentiation in the inner ear by extracellular signals and transcriptional regulators. Nelson JC, Hosamani IV, Groves AK. Curr Top Dev Biol. 2025;165:1-44. doi: 10.1016/bs.ctdb.2025.03.002. Epub 2025 Apr 3. PMID: 40973228 
  • Aging reduces motivation through decreased Bdnf expression in the ventral tegmental area.  Lei HC, Parker KE, Kuo CC, Yuede CM, McCall JG, Imai SI. Mol Psychiatry. 2025 Sep 16. doi: 10.1038/s41380-025-03253-0. PMID: 40954279
  • Raising the bar for human post-implantation embryo models Kong X, Theunissen T. Cell Stem Cell, Volume 32, Issue 10, P1479-1481, October 2, 2025
  • Echocardiographic Assessment of Pulmonary Hemodynamics and Right Ventricular Performance in Neonatal Murine Hypoxia Woo KV, Levy PT, Weinheimer CJ, Hauck AL, Hamvas A, Ornitz DM, Kovacs A, Singh GK. J Cardiovasc Dev Dis. 2025 Aug 19;12(8):316. doi: 10.3390/jcdd12080316. PMID: 40863382
  • Novel Neuroactive Steroid Analogs and Voltage-Dependent Blockers of Cav3.2 Currents, B372 and YX23, are Effective Anti-Nociceptives with Diminished Sedative Properties in Intact Female Mice Volvovitz B, Miah R, Park K, Kim JH, Vargas R, Xu Y, Qian M, Covey DF, Todorovic SM, Jevtovic-Todorovic V. Biomolecules. 2025 Aug 16;15(8):1175. doi: 10.3390/biom15081175. PMID: 40867619
  • Environmental NaCl affects Caenorhabditis elegans development and aging Pohl F, Egan BM, Schneider DL, Mosley MC, Garcia MA, Hou S, Chiu CH, Kornfeld K. Genetics. 2025 Aug 18:iyaf139. doi: 10.1093/genetics/iyaf139. PMID: 40820329
  • Notch signaling in germ line stem cells controls reproductive aging in Caenorhabditis elegans Kocsisova Z, Bagatelas ED, Santiago-Borges J, Lei HC, Egan BM, Mosley MC, Anderson AM, Schneider DL, Schedl T, Kornfeld K. PNAS Nexus. 2025 Aug 26;4(8):pgaf220. doi: 10.1093/pnasnexus/pgaf220. eCollection 2025 Aug. PMID: 40874029
  • Manifold roles of CCR7 chemokine GPCR in differentiation of human trophoblast into extravillous and syncytiotrophoblast lineage Yoon EJ, Beltcheva M, Ali SS, Fu S, Yang A, Dong C, Zemke JE, Karvas RM, Chang CT, Fischer LA, Gontarz P, Zhang B, Dietmann S, Theunissen TW, Solnica-Krezel L. Development. 2025 Sep 1:dev.204309. doi: 10.1242/dev.204309. PMID: 40888738
  • Electrophysiological Characterization of Sex-Dependent Hypnosis by an Endogenous Neuroactive Steroid Epipregnanolone Timic Stamenic T, Coulter I, Covey DF, Todorovic SM. Biomolecules. 2025 Jul 17;15(7):1033. doi: 10.3390/biom15071033. PMID: 40723904 
  • A survey of hypothalamic phenotypes identifies molecular and behavioral consequences of MYT1L haploinsufficiency in male and female mice Maloney SE, McCullough KB, Chaturvedi SM, Selmanovic D, Chase R, Chen J, Wu S, Granadillo JL, Kroll KL, Dougherty JD. Horm Behav. 2025 Jul 28;174:105796. doi: 10.1016/j.yhbeh.2025.105796. Online ahead of print. PMID: 40729938
  • Resolving the design principles that control post-natal vascular growth and scaling Pi D, Braun J, Dutta S, Patra D, Bougaran P, Mompeón A, Ma F, Stock SR, Choi S, García-Ortega L, Pratama MY, Pichardo D, Ramkhelawon B, Benedito R, Bautch VL, Ornitz DM, Goyal Y, Iruela-Arispe ML. Cell Syst. 2025 Jul 16;16(7):101324. doi: 10.1016/j.cels.2025.101324. Epub 2025 Jul 7. PMID: 40628258
  • Mechanisms underpinning spontaneous spinal cord regeneration Tendolkar A, Mokalled MH. Development. 2025 Oct 15;152(20):dev204790. doi: 10.1242/dev.204790. Epub 2025 Jul 30. PMID: 40735892.
  • NFIA regulates articular chondrocyte fatty acid metabolism and joint homeostasis Wang C, Fang L, Shi M, Niu X, Li T, Li X, Cho K, He Y, Liu S, Lu A, Xing X, Lukowski J, Goo YA, Speakman JR, Chen D, O’Keefe RJ, Patti GJ, Zuscik MJ, Zhang B, Shen J.Sci Transl Med. 2025 Jul 30;17(809):eadm9488. doi: 10.1126/scitranslmed.adm9488. Epub 2025 Jul 30.PMID: 40737429
  • Comparative electrophysiological study of neuroactive steroid-induced hypnosis in mice: sex and drug-specific differences Martin A, Coulter I, Cox R, Covey DF, Todorovic SM, Timic Stamenic T.Exp Biol Med (Maywood). 2025 Jun 10;250:10550. doi: 10.3389/ebm.2025.10550. eCollection 2025.PMID: 40557248 
  • Regulation of the Yolk Microtubule and Actin Cytoskeleton by Dachsous Cadherins during Zebrafish Epiboly Castelvecchi G, Li L, Shin J, Li-Villarreal N, Roszko I, Gontarz P, Li T, Zhang B, Sepich D, Solnica-Krezel L.bioRxiv [Preprint]. 2025 May 14:2025.05.10.653271. doi: 10.1101/2025.05.10.653271.PMID: 40463075
  • Unravelling the multifaceted actions of neurosteroids: Machine learning and in vitro screening for novel target discovery Kumar A, Qian M, Xu Y, Benz A, Covey DF, Zorumski CF, Mennerick S.Br J Pharmacol. 2025 Jun 24. doi: 10.1111/bph.70114. Online ahead of print.PMID: 40555397
  • SARM1 is an essential component of neuronal Parthanatos Wu T, Yuan L, Sasaki Y, Buchser W, Bloom AJ, DiAntonio A, Milbrandt J.bioRxiv [Preprint]. 2025 May 15:2025.05.14.654090. doi: 10.1101/2025.05.14.654090.PMID: 40463025 
  • Suppressing phagocyte activation by overexpressing the phosphatidylserine lipase ABHD12 preserves sarmopathic nerves Dingwall CB, Sasaki Y, Strickland A, Wu T, Summers DW, Bloom AJ, DiAntonio A, Milbrandt J.iScience. 2025 May 9;28(6):112626. doi: 10.1016/j.isci.2025.112626. eCollection 2025 Jun 20.PMID: 40496808 
  • V2b Neurons Act via Multiple Targets to Produce in Phase Inhibition during Locomotion Sengupta M, Bertram A, Zhu SI, Goodhill GJ, Bagnall MW.J Neurosci. 2025 Jul 16;45(29):e1530242025. doi: 10.1523/JNEUROSCI.1530-24.2025.PMID: 40506243
  • Proliferation of Early and Mature Osteoblasts Is Required for Bone Fracture Healing in Mice. Gould NR, Coello AF, McKenzie JA, Li T, Hixon KR, Chen L, Barwick K, Lee T, Obaji M, Zhang B, Ornitz DM, Silva MJ. bioRxiv [Preprint]. 2025 May 31:2025.05.27.656371. doi: 10.1101/2025.05.27.656371. PMID: 40501538
  • Regulation of Hippo signaling and planar cell polarity via distinct regions of the Fat intracellular domain. Julick CR, Thanintorn N, Zhang H, Tsatskis Y, Glaeser M, Qu Y, Rusch J, McNeill H. Development. 2025 May 16:dev.204694. PMID: 40377178
  • Mechanisms underpinning spontaneous spinal cord regeneration Tendolkar A, Mokalled MH. Development. 2025 Oct 15;152(20):dev204790. doi: 10.1242/dev.204790. Epub 2025 Jul 30. PMID: 40735892.
  • Loss of intracellular FGF14 (iFGF14) increases excitability of mature hippocampal pyramidal neurons. Ransdell JL, Carrasquillo Y, Bosch MK, Mellor RL, Ornitz DM, Nerbonne JM. J Gen Physiol. 2025 Jul 7;157(4):e202413597.PMID: 40323232
  • Diverse cell types establish a pathogenic immune environment in peripheral neuropathy. Choi J, Strickland A, Loo HQ, Dong W, Barbar L, Bloom AJ, Sasaki Y, Jin SC, DiAntonio A, Milbrandt J. J Neuroinflammation. 2025 May 23;22(1):138. PMID: 40410792
  • STAR Locally Prolongs Effective Refractory Period and Increases Ventricular Tachycardia Cycle Length Without Short-Term Scar Formation or Functional Decline: Insights From a Translational Porcine Model Study. Zenger B, Smith TW, Hicks S, Ng S, Pavek T, Knutson N, Samson P, Zheng J, Berberet C, Ibrahim EH, Jani V, Tabor J, Wilson L, Jordan SD, Marut L, Kumar A, Manikandan S, Javaheri A, Bergom C, Schwarz JK, Boyle PM, Hugo GD, Cuculich P, Robinson C, Zemlin C, Rentschler SL. Circ Arrhythm Electrophysiol. 2025 May 20:e013684. PMID: 40391432
  • Dendritic atoh1a+ cells serve as Merkel cell precursors during skin development and regeneration. Craig EW, Black EC, Fernandes SZ, Ferdous AS, Goo CEA, Sargent SM, Quitevis EJA, Swearer AA, Yee NG, Shin J, Solnica-Krezel L, Rasmussen JP. Development. 2025 Jun 2:dev.204810.PMID: 40446213
  • The emergence of human primordial germ cell-like cells in stem cell-derived gastruloids. Neupane J, Lubatti G, Gross-Thebing T, Ruiz Tejada Segura ML, Butler R, Gross-Thebing S, Dietmann S, Scialdone A, Surani MA. Sci Adv. 2025 Mar 28;11(13):eado1350. PMID: 40138398
  • VMS-Fish: A Comprehensive Application for Zebrafish Husbandry Management. Muraleedharan Saraswathy V, Mokalled MH. Zebrafish. 2025 Apr;22(2):59-63. PMID: 40195949
  • Cell expansion for notochord mechanics and endochondral bone lengthening in zebrafish depends on the 5′-inositol phosphatase Inppl1a. Voigt B, Frazier K, Yazdi D, Klein J, Gontarz P, Zhang B, Sepich DS, Mo J, Smeeton J, Solnica-Krezel L, Gray RS. Curr Biol. 2025 Apr 7:S0960-9822(25)00307-0. PMID: 40209709
  • Requirements for the neurodevelopmental disorder-associated gene ZNF292 in human cortical interneuron development and function. Kaushik K, Chapman G, Prakasam R, Batool F, Saleh M, Determan J, Huettner JE, Kroll KL. Cell Rep. 2025 Apr 20;44(5):115597. PMID: 40257863
  • Temporal regulation of endoderm convergence and extension by the BMP activity gradient through mesoderm-dependent and independent mechanisms. Chang CT, Tsai T, Solnica-Krezel L. Cells Dev. 2025 Mar 14:204021. PMID: 40090551
  • YTHDC1 cooperates with the THO complex to prevent RNA-damage-induced DNA breaks. Tsao N, Lombardi PM, Park A, Olabode J, Rodell R, Sun H, Padmanaban S, Brickner JR, Tsai MS, Pollina EA, Chen CK, Mosammaparast N. Mol Cell. 2025 Mar 20;85(6):1085-1100.e9.PMID: 40037355
  • New directions in neurosteroid therapeutics in neuropsychiatry. Zorumski CF, Covey DF, Izumi Y, Evers AS, Maguire JL, Mennerick SJ. Neurosci Biobehav Rev. 2025 Mar 22;172:106119. PMID: 40127877
  • Lifespan in rodents with MYT1L heterozygous mutation. Schreiber A, Swift RG, Wilson L, Kroll KL, Dougherty JD, Maloney SE. Sci Rep. 2025 Feb 10;15(1):4998. PMID: 39930023
  • Tracking and mitigating imprint erasure during induction of naive human pluripotency at single-cell resolution. Fischer LA, Meyer B, Reyes M, Zemke JE, Harrison JK, Park KM, Wang T, Jüppner H, Dietmann S, Theunissen TW. Stem Cell Reports. 2025 Feb 8:102419. PMID: 39952244
  • Autism- and intellectual disability-associated MYT1L mutation alters human cortical interneuron differentiation, maturation, and physiology. Prakasam R, Determan J, Chapman G, Narasimhan M, Shen R, Saleh M, Kaushik K, Gontarz P, Meganathan K, Hakim B, Zhang B, Huettner JE, Kroll KL. Stem Cell Reports. 2025 Feb 15:102421. PMID: 40020682. Stem Cell Reports. 2025 Feb 15:102421. PMID: 40020682
  • Phosphorylation of CRYAB induces a condensatopathy to worsen post-myocardial infarction left ventricular remodeling. Islam M, Rawnsley DR, Ma X, Navid W, Zhao C, Guan X, Foroughi L, Murphy JT, Navid H, Weinheimer CJ, Kovacs A, Nigro J, Diwan A, Chang RP, Kumari M, Young ME, Razani B, Margulies KB, Abdellatif M, Sedej S, Javaheri A, Covey DF, Mani K, Diwan A. J Clin Invest. 2025 Feb 11:e163730. PMID: 39932799
  • Gastric hypoplasia in mice lacking fibroblast growth factor 9 – PubMed. Mills JC, Thanintorn N, Yin Y, McNeill H, Ornitz DM, Willet SG. Dev Dyn. 2025 Mar 1. PMID: 38602479
  • SARM1 Inhibition Maintains Axonal Integrity After Rat Sciatic Nerve Transection and Repair. Sachar R, Lee TY, DiAntonio A, Dy CJ, Wever J, Milbrandt J, Brogan DM. J Hand Surg Am. 2025 Jan 29:S0363-5023(24)00617-8. PMID: 39895440
  • PMP2+ Schwann cells maintain the survival of large-caliber motor axons. Kozlowski MM, Strickland A, Morales Benitez A, Schmidt RE, Bloom AJ, Milbrandt J, DiAntonio A. J Neurosci. 2025 Jan 29:e1362242025. PMID: 39880678
  • RSK1 is an exploitable dependency in myeloproliferative neoplasms and secondary acute myeloid leukemia. Kong T, Laranjeira ABA, Letson CT, Yu L, Lin S, Fowles JS, Fisher DAC, Ng S, Yang W, He F, Youn M, Mark K, Jose AS, Liu J, Kim AB, Cox MJ, Fulbright MC, Jayanthan A, Los G, Rentschler SL, Ding L, Sakamoto KM, Dunn SE, Challen GA, Oh ST. Nat Commun. 2025 Jan 16;16(1):492. .PMID: 39820365
  • Endogenous and fluorescent sterols reveal the molecular basis for ligand selectivity of human sterol transporters. Depta L, Bryce-Rogers HP, Dekker NJ, Bønke AW, Camporese N, Qian M, Xu Y, Covey DF, Laraia L.J Lipid Res. 2024 Dec 31;66(2):100738. PMID: 39746449 
  • Fate erasure logic of gene networks underlying direct neuronal conversion of somatic cells by microRNAs. Cates K, Yuan L, Yang Y, Yoo AS. Cell Rep. 2025 Jan 28;44(1):115153. PMID: 39756035
  • Protocol to study inter-tissue communication between the hypothalamus and white adipose tissue and lifespan using a chemogenetic approach in aged mice. Tokizane K, Imai SI. STAR Protoc. 2025 Jan 10;6(1):103551. PMID: 39798096
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