2020 Publications

• Direct Neuronal Reprogramming of Common Marmoset Fibroblasts by ASCL1, microRNA-9/9*, and microRNA-124 Overexpression. Nemoto A, Kobayashi R, Yoshimatsu S, Sato Y, Kondo T, Yoo AS, Shiozawa S, Okano H. Cells. 2020 Dec 22;10(1):6.
• Video-based Learning in Surgery: Establishing Surgeon Engagement and Utilization of Variable-duration Videos. Yee A, Padovano WM, Fox IK, Hill EJR, Rowe AG, Brunt LM, Moore AM, Snyder-Warwick AK, Kahn LC, Wood MD, Coert JH, Mackinnon SE. Ann Surg. 2020 Dec;272(6):1012-1019.
• Preemptive Analgesic Effect of Intrathecal Applications of Neuroactive Steroids in a Rodent Model of Post-Surgical Pain: Evidence for the Role of T-Type Calcium Channels. Tat QL, Joksimovic SM, Krishnan K, Covey DF, Todorovic SM, Jevtovic-Todorovic V. Cells. 2020 Dec 12;9(12):2674.
• MYH3-associated distal arthrogryposis zebrafish model is normalized with para-aminoblebbistatin. Whittle J, Antunes L, Harris M, Upshaw Z, Sepich DS, Johnson AN, Mokalled M, Solnica-Krezel L, Dobbs MB, Gurnett CA. EMBO Mol Med. 2020 Oct 5;12(11):e12356. 
• Liposomes embedded within fibrin gels facilitate localized macrophage manipulations within nerve.  Pan D, Sayanagi J, Acevedo-Cintrón JA, Schellhardt L, Snyder-Warwick AK, Mackinnon SE, Wood MD. J Neurosci Methods. 2020 Oct 17:108981. 
• Incidence of Nerve Injury After Extremity Trauma in the United States. Padovano WM, Dengler J, Patterson MM, Yee A, Snyder-Warwick AK, Wood MD, Moore AM, Mackinnon SE. Hand (N Y). 2020 Oct 21:1558944720963895.
• Zinc homeostasis and signaling in the roundworm C. elegans. Earley BJ, Mendoza AD, Tan CH, Kornfeld K. Biochim Biophys Acta Mol Cell Res. 2020 Oct 2;1868(1):118882.
• SARM1 depletion rescues NMNAT1-dependent photoreceptor cell death and retinal degeneration. Sasaki Y, Kakita H, Kubota S, Sene A, Lee TJ, Ban N, Dong Z, Lin JB, Boye SL, DiAntonio A, Boye SE, Apte RS, Milbrandt J. Elife. 2020 Oct 27;9:e62027.

• Burst mitofusin activation reverses neuromuscular dysfunction in murine CMT2A. Franco A, Dang X, Walton EK, Ho JN, Zablocka B, Ly C, Miller TM, Baloh RH, Shy ME, Yoo AS, Dorn GW 2nd. Elife. 2020 Oct 19;9:e61119.

• A neuroactive steroid with a therapeutically interesting constellation of actions at GABAA and NMDA receptors. Ziolkowski L, Mordukhovich I, Chen DM, Chisari M, Shu HJ, Lambert PM, Qian M, Zorumski CF, Covey DF, Mennerick S. Neuropharmacology. 2020 Oct 23:108358. 

• Membrane organization and intracellular transport of a fluorescent analogue of 27-hydroxycholesterol. Szomek M, Moesgaard L, Reinholdt P, Haarhøj Hald SB, Petersen D, Krishnan K, Covey DF, Kongsted J, Wüstner D. Chem Phys Lipids. 2020 Oct 31;233:105004. 
• The Fgf8 subfamily (Fgf8, Fgf17 and Fgf18) is required for closure of the embryonic ventral body wall. Boylan M, Anderson MJ, Ornitz DM, Lewandoski M. Development. 2020 Oct 19;147(21):dev189506.
• SS-31 and NMN: Two paths to improve metabolism and function in aged hearts. Whitson JA, Bitto A, Zhang H, Sweetwyne MT, Coig R, Bhayana S, Shankland EG, Wang L, Bammler TK, Mills KF, Imai SI, Conley KE, Marcinek DJ, Rabinovitch PS. Aging Cell. 2020 Oct;19(10):e13213. 
• Deconstructing Stepwise Fate Conversion of Human Fibroblasts to Neurons by MicroRNAs. Cates K, McCoy MJ, Kwon JS, Liu Y, Abernathy DG, Zhang B, Liu S, Gontarz P, Kim WK, Chen S, Kong W, Ho JN, Burbach KF, Gabel HW, Morris SA, Yoo AS. Cell Stem Cell. 2020 Sep 17:S1934-5909(20)30411-2.
• Site-specific effects of neurosteroids on GABAA receptor activation and desensitization. Sugasawa Y, Cheng WW, Bracamontes JR, Chen ZW, Wang L, Germann AL, Pierce SR, Senneff TC, Krishnan K, Reichert DE, Covey DF, Akk G, Evers AS. Elife. 2020 Sep 21;9:e55331.
• Chamber-specific transcriptional responses in atrial fibrillation. Lipovsky CE, Jimenez J, Guo Q, Li G, Yin T, Hicks SC, Bhatnagar S, Takahashi K, Zhang DM, Brumback BD, Goldsztejn U, Nadadur RD, Perez-Cervantez C, Moskowitz IP, Liu S, Zhang B, Rentschler SL. JCI Insight. 2020 Sep 17;5(18):e135319.
• Ancestral roles of atypical cadherins in planar cell polarity. Brooun M, Klimovich A, Bashkurov M, Pearson BJ, Steele RE, McNeill H. Proc Natl Acad Sci U S A. 2020 Aug 11;117(32):19310-19320.

• The NEMP family supports metazoan fertility and nuclear envelope stiffness. Tsatskis Y, Rosenfeld R, Pearson JD, Boswell C, Qu Y, Kim K, Fabian L, Mohammad A, Wang X, Robson MI, Krchma K, Wu J, Gonçalves J, Hodzic D, Wu S, Potter D, Pelletier L, Dunham WH, Gingras AC, Sun Y, Meng J, Godt D, Schedl T, Ciruna B, Choi K, Perry JRB, Bremner R, Schirmer EC, Brill JA, Jurisicova A, McNeill H. Sci Adv. 2020 Aug 28;6(35):eabb4591.
• Cellular diversity of the regenerating caudal fin. Hou Y, Lee HJ, Chen Y, Ge J, Osman FOI, McAdow AR, Mokalled MH, Johnson SL, Zhao G, Wang T. Sci Adv. 2020 Aug 12;6(33):eaba2084.
• The T-type calcium channel isoform Cav3.1 is a target for the hypnotic effect of the anaesthetic neurosteroid (3β,5β,17β)-3-hydroxyandrostane-17-carbonitrile. Timic Stamenic T, Feseha S, Manzella FM, Wallace D, Wilkey D, Corrigan T, Fiedler H, Doerr P, Krishnan K, Raol YH, Covey DF, Jevtovic-Todorovic V, Todorovic SM. Br J Anaesth. 2020 Aug 25:S0007-0912(20)30611-5.
• FAM20B-catalyzed glycosaminoglycans control murine tooth number by restricting FGFR2b signaling. Wu J, Tian Y, Han L, Liu C, Sun T, Li L, Yu Y, Lamichhane B, D’Souza RN, Millar SE, Krumlauf R, Ornitz DM, Feng JQ, Klein O, Zhao H, Zhang F, Linhardt RJ, Wang X. BMC Biol. 2020 Jul 14;18(1):87.
• The Effects of Intraoperative Electrical Stimulation on Regeneration and Recovery After Nerve Isograft Repair in a Rat Model. Keane GC, Pan D, Roh J, Larson EL, Schellhardt L, Hunter DA, Snyder-Warwick AK, Moore AM, Mackinnon SE, Wood MD. Hand (N Y). 2020 Jul 15:1558944720939200.
• T cells modulate IL-4 expression by eosinophil recruitment within decellularized scaffolds to repair nerve defects. Pan D, Hunter DA, Schellhardt L, Fuchs A, Halevi AE, Snyder-Warwick AK, Mackinnon SE, Wood MD. Acta Biomater. 2020 Aug;112:149-163.

• Geminin is required for Hox gene regulation to pattern the developing limb. Lewis EMA, Sankar S, Tong C, Patterson ES, Waller LE, Gontarz P, Zhang B, Ornitz DM, Kroll KL. Dev Biol. 2020 Aug 1;464(1):11-23. doi: 10.1016/j.ydbio.2020.05.007.

• SARM1 acts downstream of neuroinflammatory and necroptotic signaling to induce axon degeneration. Ko KW, Milbrandt J, DiAntonio A. J Cell Biol. 2020 Aug 3;219(8):e201912047.

• cADPR is a gene dosage-sensitive biomarker of SARM1 activity in healthy, compromised, and degenerating axons. Sasaki Y, Engber TM, Hughes RO, Figley MD, Wu T, Bosanac T, Devraj R, Milbrandt J, Krauss R, DiAntonio A. Exp Neurol. 2020 Jul;329:113252.

• Gon4l/Udu regulates cardiomyocyte proliferation and maintenance of ventricular chamber identity during zebrafish development. Budine TE, de Sena-Tomás C, Williams MLK, Sepich DS, Targoff KL, Solnica-Krezel L. Dev Biol. 2020 Jun 15;462(2):223-234.

• The Reissner Fiber Is Highly Dynamic In Vivo and Controls Morphogenesis of the Spine. Troutwine BR, Gontarz P, Konjikusic MJ, Minowa R, Monstad-Rios A, Sepich DS, Kwon RY, Solnica-Krezel L, Gray RS. Curr Biol. 2020 Jun 22;30(12):2353-2362.e3. doi: 10.1016/j.cub.2020.04.015.

• Analysis of FGF20-regulated genes in organ of Corti progenitors by translating ribosome affinity purification. Yang LM, Stout L, Rauchman M, Ornitz DM. Dev Dyn. 2020 Jun 3.

• Maternal contributions to gastrulation in zebrafish. Solnica-Krezel L. Curr Top Dev Biol. 2020;140:391-427.

• 25-Hydroxycholesterol amplifies microglial IL-1β production in an apoE isoform-dependent manner. Wong MY, Lewis M, Doherty JJ, Shi Y, Cashikar AG, Amelianchik A, Tymchuk S, Sullivan PM, Qian M, Covey DF, Petsko GA, Holtzman DM, Paul SM, Luo W. J Neuroinflammation. 2020 Jun 17;17(1):192.

• Domain-centric database to uncover structure of minimally characterized viral genomes. Bramley JC, Yenkin AL, Zaydman MA, DiAntonio A, Milbrandt JD, Buchser WJ. Sci Data. 2020 Jun 25;7(1):202.

• Neuroactive steroids alphaxalone and CDNC24 are effective hypnotics and potentiators of GABAA currents, but are not neurotoxic to the developing rat brain. Tesic V, Joksimovic SM, Quillinan N, Krishnan K, Covey DF, Todorovic SM, Jevtovic-Todorovic V. Br J Anaesth. 2020 May;124(5):603-613.
• Models of Axon Degeneration in Drosophila Larvae. Brace EJ, DiAntonio A. Methods Mol Biol. 2020;2143:311-320.
• Cholesterol Stabilizes TAZ in Hepatocytes to Promote Experimental Non-alcoholic Steatohepatitis. Wang X, Cai B, Yang X, Sonubi OO, Zheng Z, Ramakrishnan R, Shi H, Valenti L, Pajvani UB, Sandhu J, Infante RE, Radhakrishnan A, Covey DF, Guan KL, Buck J, Levin LR, Tontonoz P, Schwabe RF, Tabas I. Cell Metab. 2020 May 5;31(5):969-986.e7.
• The CCL2/CCR2 axis is critical to recruiting macrophages into acellular nerve allograft bridging a nerve gap to promote angiogenesis and regeneration. Pan D, Acevedo-Cintrón JA, Sayanagi J, Snyder-Warwick AK, Mackinnon SE, Wood MD. Exp Neurol. 2020 May 23;331:113363.
• Inpatient Versus Outpatient Management of Negative Pressure Wound Therapy in Pediatric Patients. Santosa KB, Keane AM, Keller M, Olsen MA, Sears ED, Snyder-Warwick AK. J Surg Res. 2020 May 22;254:197-205.
• A Simple Apparatus for Individual C. elegans Culture. Pittman WE, Sinha DB, Kinser HE, Patil NS, Terry ES, Plutzer IB, Hong J, Pincus Z. Methods Mol Biol. 2020;2144:29-45.
• Design-Based stereology and binary image histomorphometry in nerve assessment. Hunter DA, Pan D, Wood MD, Snyder-Warwick AK, Moore AM, Feldman EL, Mackinnon SE, Brenner MJ. J Neurosci Methods. 2020 Apr 15;336:108635.
• Nodal and planar cell polarity signaling cooperate to regulate zebrafish convergence and extension gastrulation movements. Williams ML, Solnica-Krezel L. Elife. 2020 Apr 22;9:e54445.
• The SARM1 axon degeneration pathway: control of the NAD+ metabolome regulates axon survival in health and disease. Figley MD, DiAntonio A. Curr Opin Neurobiol. 2020 Apr 17;63:59-66.
• CellTagging: combinatorial indexing to simultaneously map lineage and identity at single-cell resolution. Kong W, Biddy BA, Kamimoto K, Amrute JM, Butka EG, Morris SA. Nat Protoc . 2020 Mar;15(3):750-772.
• FGF9 and FGF10 activate distinct signaling pathways to direct lung epithelial specification and branching. Yin Y, Ornitz DM.  Sci Signal . 2020 Mar 3;13(621):eaay4353.
• The cartilage matrisome in adolescent idiopathic scoliosis. Wise CA, Sepich D, Ushiki A, Khanshour AM, Kidane YH, Makki N, Gurnett CA, Gray RS, Rios JJ, Ahituv N, Solnica-Krezel L. Bone Res. 2020 Mar 9;8:13.
• Derivation of trophoblast stem cells from naïve human pluripotent stem cells. Dong C, Beltcheva M, Gontarz P, Zhang B, Popli P, Fischer LA, Khan SA, Park KM, Yoon EJ, Xing X, Kommagani R, Wang T, Solnica-Krezel L, Theunissen TW. Elife. 2020 Feb 12;9:e52504.
• The neurosteroid allopregnanolone protects retinal neurons by effects on autophagy and GABRs/GABAA receptors in rat glaucoma models. Ishikawa M, Takaseki S, Yoshitomi T, Covey DF, Zorumski CF, Izumi Y. Autophagy. 2020 Feb 27:1-18.
• Subverting Hedgehog Protein Autoprocessing by Chemical Induction of Paracatalysis. Smith CJ, Wagner AG, Stagnitta RT, Xu Z, Pezzullo JL, Giner JL, Xie J, Covey DF, Wang C, Callahan BP. Biochemistry. 2020 Feb 18;59(6):736-741.
• FGF signaling directs myotube guidance by regulating Rac activity. Yang S, Weske A, Du Y, Valera JM, Johnson AN. Development. 2020 Jan 13. pii: dev.183624.
• Evaluation of Multidisciplinary Team Clinic for Patients With Isolated Cleft Lip. Padovano WM, Snyder-Warwick AK, Skolnick GB, Pfeifauf KD, Menezes MD, Grames LM, Cheung S, Kim AM, Cradock MM, Naidoo SD, Patel KB. Cleft Palate Craniofac J. 2020 Jan 21:1055665619900625.
• One Multidisciplinary Cleft and Craniofacial Team’s Experience in Shifting to Family-Centered Care. Pfeifauf KD, Snyder-Warwick AK, Scheve S, Grellner CL, Skolnick GB, Wilkey A, Foy J, Naidoo SD, Patel KB. Cleft Palate Craniofac J. 2020 Jan 17:1055665619899518.
• Mouse genetics identifies unique and overlapping functions of fibroblast growth factor receptors in keratinocytes. Meyer M, Ben-Yehuda Greenwald M, Rauschendorfer T, Sänger C, Jukic M, Iizuka H, Kubo F, Chen L, Ornitz DM, Werner S. J Cell Mol Med. 2020 Jan;24(2):1774-1785.
• Identification of a FGF18-expressing alveolar myofibroblast that is developmentally cleared during alveologenesis. Hagan AS, Zhang B, Ornitz DM. Development. 2020 Jan 17;147(2).
• Huntington’s Disease Pathogenesis Is Modified In Vivo by Alfy/Wdfy3 and Selective Macroautophagy. Fox LM, Kim K, Johnson CW, Chen S, Croce KR, Victor MB, Eenjes E, Bosco JR, Randolph LK, Dragatsis I, Dragich JM, Yoo AS, Yamamoto A. Neuron. 2019 Dec 23.