2019 Publications - Developmental Biology

C ellular and molecular characterization of multiplex autism in human induced pluripotent stem cell-derived neurons. Lewis EMA, Meganathan K, Baldridge D, Gontarz P, Zhang B, Bonni A, Constantino JN, Kroll KL. Mol Autism. 2019 Dec 30;10:51.
FGFR2 is Required for AEC2 Homeostasis and Survival Following Bleomycin-Induced Lung Injury. Dorry SJ, Ansbro BO, Ornitz DM, Mutlu GM, Guzy RD. Am J Respir Cell Mol Biol. 2019 Dec 20.
Fat/Dachsous family cadherins in cell and tissue organisation. Fulford AD, McNeill H. Curr Opin Cell Biol. 2019 Nov 15;62:96-103.
DLK Activation Synergizes with Mitochondrial Dysfunction to Downregulate Axon Survival Factors and Promote SARM1-Dependent Axon Degeneration. Summers DW, Frey E, Walker LJ, Milbrandt J, DiAntonio A. Mol Neurobiol. 2019 Nov 7.
Novel neuroactive steroid with hypnotic and T-channel blocking properties exerts effective analgesia in a rodent model of post-surgical pain. Joksimovic SL, Joksimovic SM, Manzella FM, Asnake B, Orestes P, Raol YH, Krishnan K, Covey DF, Jevtovic-Todorovic V, Todorovic SM. Br J Pharmacol. 2019 Nov 15.
Too much or too little? A systematic review of postparetic synkinesis treatment. Lapidus JB, Lu JC, Santosa KB, Yaeger LH, Stoll C, Colditz GA, Snyder-Warwick A. J Plast Reconstr Aesthet Surg. 2019 Oct 11.
Recent insights into the naïve state of human pluripotency and its applications. Dong C, Fischer LA, Theunissen TW. Exp Cell Res. 2019 Dec 1;385(1):111645.
SIK3 suppresses neuronal hyperexcitability by regulating the glial capacity to buffer K+ and water. Li H, Russo A, DiAntonio A. J Cell Biol. 2019 Oct 23. pii: jcb.201907138.
Cholesterol accessibility at the ciliary membrane controls Hedgehog signaling. Kinnebrew M, Iverson EJ, Patel BB, Pusapati GV, Kong JH, Johnson KA, Luchetti G, Eckert KM, McDonald JG, Covey DF, Siebold C, Radhakrishnan A, Rohatgi R. Elife. 2019 Oct 28;8. pii: e50051.
β-Catenin is required for radial cell patterning and identity in the developing mouse cochlea. Jansson L, Ebeid M, Shen JW, Mokhtari TE, Quiruz LA, Ornitz DM, Huh SH, Cheng AG. Proc Natl Acad Sci U S A. 2019 Oct 15;116(42):21054-21060.
The morphogen Sonic hedgehog inhibits its receptor Patched by a pincer grasp mechanism. Rudolf AF, Kinnebrew M, Kowatsch C, Ansell TB, El Omari K, Bishop B, Pardon E, Schwab RA, Malinauskas T, Qian M, Duman R, Covey DF, Steyaert J, Wagner A, Sansom MSP, Rohatgi R, Siebold C. Nat Chem Biol. 2019 Oct;15(10):975-982.
Neurosteroids as novel antidepressants and anxiolytics: GABA-A receptors and beyond. Zorumski CF, Paul SM, Covey DF, Mennerick S. Neurobiol Stress. 2019 Sep 27;11:100196.
Ultra-low frequency labeling of single cell lineages in Drosophila. Snee M, Lee WC, Beehler-Evans R, Micchelli CA. Dev Biol. 2019 Sep 21.
Binding and intracellular transport of 25-hydroxycholesterol by Niemann-Pick C2 protein. Petersen D, Reinholdt P, Szomek M, Hansen SK, Poongavanam V, Dupont A, Heegaard CW, Krishnan K, Fujiwara H, Covey DF, Ory DS, Kongsted J, Wüstner D. Biochim Biophys Acta Biomembr. 2019 Sep 12:183063.
FGF2-induced STAT3 activation regulates pathologic neovascularization. Dong Z, Santeford A, Ban N, Lee TJ, Smith C, Ornitz DM, Apte RS. Exp Eye Res. 2019 Oct;187:107775.
Osteocyte Death and Bone Overgrowth in Mice Lacking Fibroblast Growth Factor Receptors 1 and 2 in Mature Osteoblasts and Osteocytes. McKenzie J, Smith C, Karuppaiah K, Langberg J, Silva MJ, Ornitz DM. J Bone Miner Res. 2019 Sep;34(9):1660-1675.
Generation and validation of novel conditional flox and inducible Cre alleles targeting fibroblast growth factor 18 (Fgf18). Hagan AS, Boylan M, Smith C, Perez-Santamarina E, Kowalska K, Hung IH, Lewis RM, Hajihosseini MK, Lewandoski M, Ornitz DM. Dev Dyn. 2019 Sep;248(9):882-893.
Crouzon syndrome mouse model exhibits cartilage hyperproliferation and defective segmentation in the developing trachea. Hines EA, Jones MN, Harvey JF, Perlyn C, Ornitz DM, Sun X, Verheyden JM. Sci China Life Sci. 2019 Aug 26.
Wnd/DLK Is a Critical Target of FMRP Responsible for Neurodevelopmental and Behavior Defects in the Drosophila Model of Fragile X Syndrome. Russo A, DiAntonio A. Cell Rep. 2019 Sep 3;28(10):2581-2593.e5.
Extracellular Vesicle-Contained eNAMPT Delays Aging and Extends Lifespan in Mice. Yoshida M, Satoh A, Lin JB, Mills KF, Sasaki Y, Rensing N, Wong M, Apte RS, Imai SI. Cell Metab. 2019 Aug 6;30(2):329-342.e5.
Mechanism of Action of VP1-001 in cryAB(R120G)-Associated and Age-Related Cataracts. Molnar KS, Dunyak BM, Su B, Izrayelit Y, McGlasson-Naumann B, Hamilton PD, Qian M, Covey DF, Gestwicki JE, Makley LN, Andley UP. Invest Ophthalmol Vis Sci. 2019 Aug 1;60(10):3320-3331.
TIR domains of plant immune receptors are NAD+-cleaving enzymes that promote cell death. Wan L, Essuman K, Anderson RG, Sasaki Y, Monteiro F, Chung EH, Osborne Nishimura E, DiAntonio A, Milbrandt J, Dangl JL, Nishimura MT. Science. 2019 Aug 23;365(6455):799-803.
What is Normal? Neuromuscular junction reinnervation after nerve injury. Vannucci B, Santosa KB, Keane AM, Jablonka-Shariff A, Lu CY, Yan Y, MacEwan M, Snyder-Warwick AK. Muscle Nerve. 2019 Aug 13.
Comparing electrical stimulation and tacrolimus (FK506) to enhance treating nerve injuries. Jo S, Pan D, Halevi AE, Roh J, Schellhardt L, Hunter Ra DA, Snyder-Warwick AK, Moore AM, Mackinnon SE, Wood MD. Muscle Nerve. 2019 Aug 9.
What is Normal? Neuromuscular junction reinnervation after nerve injury. Vannucci B, Santosa KB, Keane AM, Jablonka-Shariff A, Lu CY, Yan Y, MacEwan M, Snyder-Warwick AK.Muscle Nerve. 2019 Aug 13.
Sox2 and FGF20 interact to regulate organ of Corti hair cell and supporting cell development in a spatially-graded manner. Yang LM, Cheah KSE, Huh SH, Ornitz DM. PLoS Genet. 2019 Jul 5;15(7):e1008254.
Surgical, Speech, and Audiologic Outcomes in Patients With Orofacial Cleft and Van der Woude Syndrome. Kitchin S, Grames L, Naidoo SD, Skolnick G, Schoenborn A, Snyder-Warwick A, Patel K. J Craniofac Surg. 2019 Jul;30(5):1484-1487.
MicroRNAs as modulators of longevity and the aging process. Kinser HE, Pincus Z. Hum Genet. 2019 Jul 11.
Transcriptional and Epigenetic Regulation of Cardiac Electrophysiology. Jimenez J, Rentschler SL. Pediatr Cardiol. 2019 Jul 25.
The evolving concept of cell identity in the single cell era. Morris SA. Development. 2019 Jun 27;146(12). pii: dev169748.
Single-Cell Analysis Reveals Regional Reprogramming During Adaptation to Massive Small Bowel Resection in Mice. Seiler KM, Waye SE, Kong W, Kamimoto K, Bajinting A, Goo WH, Onufer EJ, Courtney C, Guo J, Warner BW, Morris SA.Cell Mol Gastroenterol Hepatol. 2019 Jun 10.
Multiple neurosteroid and cholesterol binding sites in voltage-dependent anion channel-1 determined by photo-affinity labeling. Cheng WWL, Budelier MM, Sugasawa Y, Bergdoll L, Queralt-Martín M, Rosencrans W, Rostovtseva TK, Chen ZW, Abramson J, Krishnan K, Covey DF, Whitelegge JP, Evers AS. Biochim Biophys Acta Mol Cell Biol Lipids. 2019 Oct;1864(10):1269-1279.
Cleft and Craniofacial Multidisciplinary Team Clinic: A Look at Attrition Rates for Patients With Complete Cleft Lip and Palate and Nonsyndromic Single-Suture Craniosynostosis. Cooper DC, Peterson EC, Grellner CG, Naidoo SD, Skolnick GB, Pfeifauf KD, Smyth MD, Snyder-Warwick AK, Patel KB. Cleft Palate Craniofac J. 2019 Jun 13
Comparison of Myelin-Associated Glycoprotein With Vincristine for Facial Nerve Inhibition After Bilateral Axotomy in a Transgenic Thy1-Gfp Rat Model. Ali SA, Hanks JE, Stebbins AW, Cohen ST, Hunter DA, Snyder-Warwick AK, Mackinnon SE, Kupfer RA, Hogikyan ND, Feldman EL, Brenner MJ. JAMA Facial Plast Surg. 2019 Jun 20.
ZMYM2 inhibits NANOG-mediated reprogramming. Lawrence M, Theunissen TW, Lombard P, Adams DJ, Silva JCR. Wellcome Open Res. 2019 Jun 6;4:88.
The molecular determinants of neurosteroid binding in the GABA(A) receptor. Sugasawa Y, Bracamontes JR, Krishnan K, Covey DF, Reichert DE, Akk G, Chen Q, Tang P, Evers AS, Cheng WWL. J Steroid Biochem Mol Biol. 2019 May 28;192:105383.
A translational rheostat integrates euchromatin regulation and growth of pluripotent embryonic cells. Meganathan K, Prakasam R, Kroll KL. Stem Cell Investig. 2019 May 21;6:11.
Rapid, population-wide declines in stem cell number and activity during reproductive aging in C. elegans. Kocsisova Z, Kornfeld K, Schedl T. Development. 2019 Apr 1. pii: dev.173195.
Negative-Pressure Wound Therapy in Infants and Children: A Population-Based Study. Santosa KB, Keller M, Olsen MA, Keane AM, Sears ED, Snyder-Warwick AK. J Surg Res. 2019 Mar;235:560-568. doi: 10.1016/j.jss.2018.10.043.
Synthesis and characterization of diazirine alkyne probes for the study of intracellular cholesterol trafficking. Feltes M, Moores S, Gale SE, Krishnan K, Mydock-McGrane L, Covey DF, Ory DS, Schaffer JE. J Lipid Res. 2019 Mar;60(3):707-716.
Neural crest-derived neurons invade the ovary but not the testis during mouse gonad development. McKey J, Bunce C, Batchvarov IS, Ornitz DM, Capel B. Proc Natl Acad Sci U S A. 2019 Mar 19;116(12):5570-5575.
Homozygous frameshift mutations in FAT1 cause a syndrome characterized by colobomatous-microphthalmia, ptosis, nephropathy and syndactyly. Lahrouchi N, George A, Ratbi I, Schneider R, Elalaoui SC, Moosa S, Bharti S, Sharma R, Abu-Asab M, Onojafe F, Adadi N, Lodder EM, Laarabi FZ, Lamsyah Y, Elorch H, Chebbar I, Postma AV, Lougaris V, Plebani A, Altmueller J, Kyrieleis H, Meiner V, McNeill H, Bharti K, Lyonnet S, Wollnik B, Henrion-Caude A, Berraho A, Hildebrandt F, Bezzina CR, Brooks BP, Sefiani A. Nat Commun. 2019 Mar 12;10(1):1180.
Fat regulates expression of four-jointed reporters in vivo through a 20 bp element independently of the Hippo pathway. Arbouzova NI, Fulford AD, Zhang H, McNeill H. Dev Biol. 2019 Mar 9.
FAT4 Fine-Tunes Kidney Development by Regulating RET Signaling. Zhang H, Bagherie-Lachidan M, Badouel C, Enderle L, Peidis P, Bremner R, Kuure S, Jain S, McNeill H. Dev Cell. 2019 Mar 25;48(6):780-792.e4.
Multiple functional neurosteroid binding sites on GABAA receptors. Chen ZW, Bracamontes JR, Budelier MM, Germann AL, Shin DJ, Kathiresan K, Qian MX, Manion B, Cheng WWL, Reichert DE, Akk G, Covey DF, Evers AS. PLoS Biol. 2019 Mar 7;17(3):e3000157.
Diagnosis and Pathophysiological Mechanisms of Group 3 Hypoxia-Induced Pulmonary Hypertension. Woo KV, Ornitz DM, Singh GK. Curr Treat Options Cardiovasc Med. 2019 Mar 22;21(3):16.
Fibroblast growth factors in skeletal development. Ornitz DM, Marie PJ. Curr Top Dev Biol. 2019;133:195-234.
Gene therapy targeting SARM1 blocks pathological axon degeneration in mice. Geisler S, Huang SX, Strickland A, Doan RA, Summers DW, Mao X, Park J, DiAntonio A, Milbrandt J. J Exp Med. 2019 Feb 4;216(2):294-303. doi: 10.1084/jem.20181040.
Novel neurosteroid hypnotic blocks T-type calcium channel-dependent rebound burst firing and suppresses long-term potentiation in the rat subiculum. Joksimovic SM, Izumi Y, Joksimovic SL, Tesic V, Krishnan K, Asnake B, Jevtovic-Todorovic V, Covey DF, Zorumski CF, Todorovic SM. Br J Anaesth. 2019 Feb 27.
The E3 ligase Highwire promotes synaptic transmission by targeting the NAD-synthesizing enzyme dNmnat. Russo A, Goel P, Brace EJ, Buser C, Dickman D, DiAntonio A. EMBO Rep. 2019 Mar;20(3). pii: e46975. doi: 10.15252/embr.201846975.
Visualizing pregnenolone sulfate-like modulators of NMDA receptor function reveals intracellular and plasma-membrane localization. Chisari M, Wilding TJ, Brunwasser S, Krishnan K, Qian M, Benz A, Huettner JE, Zorumski CF, Covey DF, Mennerick S. Neuropharmacology. 2019 Jan;144:91-103.