Sabine Dietmann, PhD
Assistant Professor of Developmental Biology and Medicine, Investigator in Informatics
- Phone: 314-362-8253
- Email: sdietmann@nospam.wustl.edu
Research interests
Single-cell transcriptomics and epigenetics, mammalian development, epitranscriptomics, transposable elements, transgenerational inheritance, neurodegenerative diseases and cancer
Education
1999 Ph.D. Theoretical Biophysics, Charité, Humboldt University, Berlin, Germany. Title
of Thesis: “Molecular interaction surfaces in proteins: analysis and prediction of protein
neighbors”
1994 Diploma in Physics, Johann Wolfgang Goethe University Frankfurt/Main, Germany Advanced studies: Biophysics, Theoretical physics, Mathematics.
Selected Publications
- Neupane J, Lubatti G, Gross-Thebing T, Ruiz Tejada Segura ML, Butler R, Gross-Thebing S, Dietmann S, Scialdone A, Surani MA. The emergence of human primordial germ cell-like cells in stem cell-derived gastruloids. Sci Adv. 2025 Mar 28;11(13):eado1350. doi: 10.1126/sciadv.ado1350. Epub 2025 Mar 26. PMID: 40138398
- Gruhn WH, Tang WWC, Dietmann S, Alves-Lopes JP, Penfold CA, Wong FCK, Ramakrishna NB, Surani MA. Epigenetic resetting in the human germ line entails histone modification remodeling. Sci Adv. 2023 Jan 18;9(3):eade1257. doi: 10.1126/sciadv.ade1257. Epub 2023 Jan 18. PubMed PMID: 36652508; PubMed Central PMCID: PMC9848478.
- Delaunay S, Pascual G, Feng B, Klann K, Behm M, Hotz-Wagenblatt A, Richter K, Zaoui K, Herpel E, Münch C, Dietmann S, Hess J, Benitah SA, Frye M. Mitochondrial RNA modifications shape metabolic plasticity in metastasis. Nature. 2022 Jul;607(7919):593-603. doi: 10.1038/s41586-022-04898-5. Epub 2022 Jun 29. PubMed PMID: 35768510; PubMed Central PMCID: PMC9300468.
- Karvas RM, Khan SA, Verma S, Yin Y, Kulkarni D, Dong C, Park KM, Chew B, Sane E, Fischer LA, Kumar D, Ma L, Boon ACM, Dietmann S, Mysorekar IU, Theunissen TW. Stem-cell-derived trophoblast organoids model human placental development and susceptibility to emerging pathogens. Cell Stem Cell. 2022 May 5;29(5):810-825.e8. doi: 10.1016/j.stem.2022.04.004. PubMed PMID: 35523141; PubMed Central PMCID: PMC9136997.
- Klatt Shaw D, Saraswathy VM, Zhou L, McAdow AR, Burris B, Butka E, Morris SA, Dietmann S, Mokalled MH. Localized EMT reprograms glial progenitors to promote spinal cord repair. Dev Cell 03/2021
- Minn KT, Dietmann S, Waye SE, Morris SA, Solnica-Krezel L. Gene expression dynamics underlying cell fate emergence in 2D micropatterned human embryonic stem cell gastruloids. Stem Cell Reports 05/2021
- Hackett JA, Kobayashi T, Dietmann S, Surani MA. Activation of lineage regulators and transposable elements across a pluripotent spectrum. Stem Cell Reports 06/2017
- Tang WWC*, Dietmann S* (co-first authors), Irie M, Leitch HG, Floros VI, Bradshaw CR, Hackett JA, Chinnery PFC, Surani MA. A Unique Gene Regulatory Network Resets the Human Germline Epigenome for Development. Cell 06/2015