Andrew S. Yoo, PhD

Associate Professor of Developmental Biology

Research interests

The general goal of my research is to understand molecular mechanisms underlying the specification of cell types and developing methods to alter the fates of cells in vitro and in vivo.

We recently discovered that small RNA molecules, microRNAs, could promote generation of post-mitotic neurons by demonstrating that expression of neuron-specific microRNAs and neural factors in non-neuronal cell types could directly reprogram their cell fates into functional neurons.

We currently aim to:

  1. Develop tissue culture models of neurological diseases using patient-specific neurons and study cell autonomous properties associated with disease states in induced neurons
  2. Identify molecular mechanisms underlying the neurogenic activity of neuron-specific microRNAs

We will use multiple interdisciplinary approaches (including molecular genetics, genomics and biochemistry) to delineate how these microRNAs promote neuronal fates.

Lab website

Education and Training

2011 – Postdoctoral fellow, Stanford University, CA, Chromatin biology and cell fate reprogramming

2005 – Ph.D. Columbia University, NY, Cellular, Molecular and Biophysical Studies

1998 – M.Sc. University of British Columbia, Vancouver, BC, Canada, Experimental Medicine (Neurology)

1995 – B.Sc. McGill University, Montreal, PQ, Canada, Physiology (with focus on Neurophysiology)

Academic Positions

August 2011 – present – Assistant Professor, Department Developmental Biology, Washington University School of Medicine

Honors and Awards

WUSM Distinguished Investigator Award, 2018

Presidential Early Career Award for Scientist and Engineers (PECASE), 2013

NIH Director’s New Innovator Award, 2012-2017

Ellison Medical Foundation New Investigator in Aging Award, 2012-2016

Mallinckrodt Foundation New Investigator Award, 2011-2013

Helen Hay Whitney Foundation Fellowship, 2007-2010

Natural Sciences and Engineering Research Council of Canada (NSERC) Postgraduate Award (for tenure at universities outside Canada), 2001-2003

Honors in Neurophysiology, McGill University, 1995

Selected publications

See a complete list of Dr. Yoo’s publications »