Congratulations to Dr. Doug Covey’s Lab on their recent publications!
The morphogen Sonic hedgehog inhibits its receptor Patched by a pincer grasp mechanism. Rudolf AF, Kinnebrew M, Kowatsch C, Ansell TB, El Omari K, Bishop B, Pardon E, Schwab RA, Malinauskas T, Qian M, Duman R, Covey DF, Steyaert J, Wagner A, Sansom MSP, Rohatgi R, Siebold C. Nat Chem Biol. 2019 Oct;15(10):975-982.
Cholesterol accessibility at the ciliary membrane controls Hedgehog signaling. Kinnebrew M, Iverson EJ, Patel BB, Pusapati GV, Kong JH, Johnson KA, Luchetti G, Eckert KM, McDonald JG, Covey DF, Siebold C, Radhakrishnan A, Rohatgi R. Elife. 2019 Oct 28;8. pii: e50051.