- Loss of function of FAM177A1, a Golgi complex localized protein, causes a novel neurodevelopmental disorder. Kohler JN, Legro NR, Baldridge D, Shin J, Bowman A, Ugur B, Jackstadt MM, Shriver LP, Patti GJ, Zhang B, Feng W, McAdow AR, Goddard P, Ungar RA, Jensen T, Smith KS, Fresard L, Alvarez R, Bonner D, Reuter CM, McCormack C, Kravets E, Marwaha S, Holt JM; Undiagnosed Diseases Network; Worthey EA, Ashley EA, Montgomery SB, Fisher PG, Postlethwait J, De Camilli P, Solnica-Krezel L, Bernstein JA, Wheeler MT. Genet Med. 2024 Sep;26(9):101166. PMID: 38767059
- VPS13B is localized at the interface between Golgi cisternae and is a functional partner of FAM177A1. Ugur B, Schueder F, Shin J, Hanna MG, Wu Y, Leonzino M, Su M, McAdow AR, Wilson C, Postlethwait J, Solnica-Krezel L, Bewersdorf J, De Camilli P. J Cell Biol. 2024 Dec 2;223(12):e202311189. PMID: 39331042
- Spatially resolved multiomics reveals the microanatomy of the human heart. Jordan S, Rentschler SL. Nat Cardiovasc Res. 2023 Sep;2(9):798-800. doi: 10.1038/s44161-023-00327-6.PMID: 39196067
- Ergosterol promotes aggregation of natamycin in the yeast plasma membrane. Szomek M, Akkerman V, Lauritsen L, Walther HL, Juhl AD, Thaysen K, Egebjerg JM, Covey DF, Lehmann M, Wessig P, Foster AJ, Poolman B, Werner S, Schneider G, Müller P, Wüstner D. Biochim Biophys Acta Biomembr. 2024 Oct;1866(7):184350. doi: 10.1016/j.bbamem.2024.184350. Epub 2024 May 27. PMID: 38806103
- Inhibitory actions of potentiating neuroactive steroids in the human α1β3γ2L GABAA receptor. Pierce SR, Germann AL, Covey DF, Evers AS, Steinbach JH, Akk G. Mol Pharmacol. 2024 Aug 30:MOLPHARM-AR-2024-000960. doi: 10.1124/molpharm.124.000960. Online ahead of print. PMID: 39214710
- Astrocyte-Neuron Interactions in Spinal Cord Injury. Reyes C, Mokalled MH. Adv Neurobiol. 2024;39:213-231. doi: 10.1007/978-3-031-64839-7_9. PMID: 39190077
- Modeling late-onset Alzheimer’s disease neuropathology via direct neuronal reprogramming. Sun Z, Kwon JS, Ren Y, Chen S, Walker CK, Lu X, Cates K, Karahan H, Sviben S, Fitzpatrick JAJ, Valdez C, Houlden H, Karch CM, Bateman RJ, Sato C, Mennerick SJ, Diamond MI, Kim J, Tanzi RE, Holtzman DM, Yoo AS. Science. 2024 Aug 2;385(6708):adl2992. doi: 10.1126/science.adl2992. Epub 2024 Aug 2. PMID: 39088624
- Multi-omic analysis of Huntington’s disease reveals a compensatory astrocyte state. Paryani F, Kwon JS, Ng CW, Jakubiak K, Madden N, Ofori K, Tang A, Lu H, Xia S, Li J, Mahajan A, Davidson SM, Basile AO, McHugh C, Vonsattel JP, Hickman R, Zody MC, Housman DE, Goldman JE, Yoo AS, Menon V, Al-Dalahmah O. Nat Commun. 2024 Aug 8;15(1):6742. doi: 10.1038/s41467-024-50626-0. PMID: 39112488
- Single-cell analysis of innate spinal cord regeneration identifies intersecting modes of neuronal repair. Saraswathy VM, Zhou L, Mokalled MH. Nat Commun. 2024 Aug 15;15(1):6808. doi: 10.1038/s41467-024-50628-y.PMID: 39147780
- Neurosteroids mediate and modulate the effects of pro-inflammatory stimulation and toll-like receptors on hippocampal plasticity and learning.
Izumi Y, O’Dell KA, Cashikar AG, Paul SM, Covey DF, Mennerick SJ, Zorumski CF. PLoS One. 2024 Jun 14;19(6):e0304481. doi: 10.1371/journal.pone.0304481. eCollection 2024.PMID: 38875235 - Single-cell lineage capture across genomic modalities with CellTag-multi reveals fate-specific gene regulatory changes. Jindal K, Adil MT, Yamaguchi N, Yang X, Wang HC, Kamimoto K, Rivera-Gonzalez GC, Morris SA. Nat Biotechnol. 2024 Jun;42(6):946-959. doi: 10.1038/s41587-023-01931-4. Epub 2023 Sep 25.PMID: 37749269
- Stem cell dynamics and cellular heterogeneity across lineage subtypes of castrate-resistant prostate cancer. Beshiri ML, Capaldo BJ, Lake R, Ku AT, Burner D, Tice CM, Tran C, Kostas J, Alilin AN, Yin J, Agarwal S, Morris SA, Karzai FH, Lotan TL, Dahut WL, Sowalsky AG, Kelly K. Stem Cells. 2024 Jun 14;42(6):526-539. doi: 10.1093/stmcls/sxae025.PMID: 38563224
- An interpretable machine learning-based cerebrospinal fluid proteomics clock for predicting age reveals novel insights into brain aging. Melendez J, Sung YJ, Orr M, Yoo A, Schindler S, Cruchaga C, Bateman R. Aging Cell. 2024 Jun 24:e14230. doi: 10.1111/acel.14230. Online ahead of print.PMID: 38923730
- Modeling Normal and Abnormal Circuit Development with Recurrent Neural Networks. Zavitz D, Ching S, Goodhill G. Cold Spring Harb Perspect Biol. 2024 Jul 15:a041507. doi: 10.1101/cshperspect.a041507. Online ahead of print.PMID: 39009416
- Rapid iPSC inclusionopathy models shed light on formation, consequence, and molecular subtype of α-synuclein inclusions. Lam I, Ndayisaba A, Lewis AJ, Fu Y, Sagredo GT, Kuzkina A, Zaccagnini L, Celikag M, Sandoe J, Sanz RL, Vahdatshoar A, Martin TD, Morshed N, Ichihashi T, Tripathi A, Ramalingam N, Oettgen-Suazo C, Bartels T, Boussouf M, Schäbinger M, Hallacli E, Jiang X, Verma A, Tea C, Wang Z, Hakozaki H, Yu X, Hyles K, Park C, Wang X, Theunissen TW, Wang H, Jaenisch R, Lindquist S, Stevens B, Stefanova N, Wenning G, van de Berg WDJ, Luk KC, Sanchez-Pernaute R, Gómez-Esteban JC, Felsky D, Kiyota Y, Sahni N, Yi SS, Chung CY, Stahlberg H, Ferrer I, Schöneberg J, Elledge SJ, Dettmer U, Halliday GM, Bartels T, Khurana V. Neuron. 2024 Jul 23:S0896-6273(24)00409-4. doi: 10.1016/j.neuron.2024.06.002. Online ahead of print.PMID: 39079530
- Direct measurements of neurosteroid binding to specific sites on GABAA receptors. Chintala SM, Tateiwa H, Qian M, Xu Y, Amtashar F, Chen ZW, Kirkpatrick CC, Bracamontes J, Germann AL, Akk G, Covey DF, Evers AS. Br J Pharmacol. 2024 Jul 8: 10.1111. PMID: 38978389
- Defining cis-regulatory elements and transcription factors that control human cortical interneuron development. Chapman G, Determan J, Jetter H, Kaushik K, Prakasam R, Kroll KL. iScience. 2024 May 11;27(6):109967. PMID: 38827400
- Loss of function of FAM177A1, a Golgi complex localized protein, causes a novel neurodevelopmental disorder. Kohler JN, Legro NR, Baldridge D, Shin J, Bowman A, Ugur B, Jackstadt MM, Shriver LP, Patti GJ, Zhang B, Feng W, McAdow AR, Goddard P, Ungar RA, Jensen T, Smith KS, Fresard L, Alvarez R, Bonner D, Reuter CM, McCormack C, Kravets E, Marwaha S, Holt JM; Undiagnosed Diseases Network; Worthey E, Ashley EA, Montgomery SB, Fisher P, Postlethwait J, De Camilli P, Solnica-Krezel L, Bernstein JA, Wheeler MT. Genet Med. 2024 May 16:101166. PMID: 38767059
- Ergosterol promotes aggregation of natamycin in the yeast plasma membrane. Szomek M, Akkerman V, Lauritsen L, Walther HL, Juhl AD, Thaysen K, Egebjerg JM, Covey DF, Lehmann M, Wessig P, Foster AJ, Poolman B, Werner S, Schneider G, Müller P, Wüstner D. Biochim Biophys Acta Biomembr. 2024 May 27;1866(7):184350. PMID: 38806103
- Cellular geometry and epithelial-mesenchymal plasticity intersect with PIEZO1 in breast cancer cells. So CL, Robitaille M, Sadras F, McCullough MH, Milevskiy MJG, Goodhill GJ, Roberts-Thomson SJ, Monteith GR. Commun Biol. 2024 Apr 17;7(1):467. PMID: 38632473
- iPSC-based modeling of preeclampsia identifies epigenetic defects in extravillous trophoblast differentiation. Morey R, Bui T, Cheung VC, Dong C, Zemke JE, Requena D, Arora H, Jackson MG, Pizzo D, Theunissen TW, Horii M. iScience. 2024 Mar 25;27(4):109569. PMID: 38623329
- Stem cell dynamics and cellular heterogeneity across lineage subtypes of castrate resistant prostate cancer. Beshiri ML, Capaldo BJ, Lake R, Ku AT, Burner D, Tice CM, Tran C, Kostas J, Alilin AN, Yin JJ, Agarwal S, Morris SA, Karzai FH, Lotan TL, Dahut WL, Sowalsky AG, Kelly K. Stem Cells. 2024 Apr 2:sxae025. PMID: 38563224
- Identification of a myofibroblast differentiation program during neonatal lung development. Yin Y, Koenitzer JR, Patra D, Dietmann S, Bayguinov P, Hagan AS, Ornitz DM. Development. 2024 Apr 11:dev.202659. PMID: 38602479
- The response of Dual-leucine zipper kinase (DLK) to nocodazole: Evidence for a homeostatic cytoskeletal repair mechanism. DeVault L, Mateusiak C, Palucki J, Brent M, Milbrandt J, DiAntonio A. PLoS One. 2024 Apr 4;19(4):e0300539. PMID: 38574058
- A unified total synthesis route to 18-trideuterated and/or 19-trideuterated testosterone, androstenedione and progesterone. Qian M, Covey DF. Steroids. 2024 May;205:109391. PMID: 38437943
- Generation of 3D Trophoblast Organoids from Human Naïve Pluripotent Stem Cells Karvas RM, Theunissen TW. Methods Mol Biol. 2024;2767:85-103. PMID: 37402094
- Comparison of Behavioral Effects of GABAergic Low- and High-Efficacy Neuroactive Steroids in the Zebrafish Larvae Assay Germann AL, Xu Y, Covey DF, Evers AS, Akk G. ACS Chem Neurosci. 2024 Mar 6;15(5):909-915. PMID: 38386612
- Lysosome-related organelles contain an expansion compartment that mediates delivery of zinc transporters to promote homeostasis Mendoza AD, Dietrich N, Tan CH, Herrera D, Kasiah J, Payne Z, Cubillas C, Schneider DL, Kornfeld K. Proc Natl Acad Sci U S A. 2024 Feb 13;121(7):e2307143121. PMID: 38330011
- GPR161 structure uncovers the redundant role of sterol-regulated ciliary cAMP signaling in the Hedgehog pathway Hoppe N, Harrison S, Hwang SH, Chen Z, Karelina M, Deshpande I, Suomivuori CM, Palicharla VR, Berry SP, Tschaikner P, Regele D, Covey DF, Stefan E, Marks DS, Reiter JF, Dror RO, Evers AS, Mukhopadhyay S, Manglik A. Nat Struct Mol Biol. 2024 Feb 7. PMID: 38326651
- Synergistic Protection of Retinal Ganglion Cells (RGCs) by SARM1 Inactivation with CNTF in a Rodent Model of Nonarteritic Anterior Ischemic Optic Neuropathy Guo Y, Mehrabian Z, Milbrandt J, DiAntonio A, Bernstein SL. Cells. 2024 Jan 23;13(3):202. PMID: 38334594
- Self-renewing human naïve pluripotent stem cells dedifferentiate in 3D culture and form blastoids spontaneously. Guo M, Wu J, Chen C, Wang X, Gong A, Guan W, Karvas RM, Wang K, Min M, Wang Y, Theunissen TW, Gao S, Silva JCR. Nat Commun. 2024 Jan 22;15(1):668. PMID: 38253551
- Neuroactive steroid effects on autophagy in a human embryonic kidney 293 (HEK) cell model. Salvatore SV, Ilagan MXG, Shu H, Lambert PM, Benz A, Qian M, Covey DF, Zorumski CF, Mennerick S. Sci Rep. 2024 Jan 10;14(1):1042. PMID: 38200205
- Absolute quantification of nicotinamide mononucleotide in biological samples by double isotope-mediated liquid chromatography-tandem mass spectrometry (dimeLC-MS/MS). Unno J, Mills KF, Ogura T, Nishimura M, Imai SI. NPJ Aging. 2024 Jan 2;10(1):2. PMID: 38167419
- Sarm1 knockout prevents type 1 diabetic bone disease in females independent of neuropathy. Brazill JM, Shen IR, Craft CS, Magee KL, Park JS, Lorenz M, Strickland A, Wee NK, Zhang X, Beeve AT, Meyer GA, Milbrandt J, DiAntonio A, Scheller EL. JCI Insight. 2024 Jan 4:e175159. PMID: 38175722
- 7-Dehydrocholesterol is an endogenous suppressor of ferroptosis. Freitas FP, Alborzinia H, Dos Santos AF, Nepachalovich P, Pedrera L, Zilka O, Inague A, Klein C, Aroua N, Kaushal K, Kast B, Lorenz SM, Kunz V, Nehring H, Xavier da Silva TN, Chen Z, Atici S, Doll SG, Schaefer EL, Ekpo I, Schmitz W, Horling A, Imming P, Miyamoto S, Wehman AM, Genaro-Mattos TC, Mirnics K, Kumar L, Klein-Seetharaman J, Meierjohann S, Weigand I, Kroiss M, Bornkamm GW, Gomes F, Netto LES, Sathian MB, Konrad DB, Covey DF, Michalke B, Bommert K, Bargou RC, Garcia-Saez A, Pratt DA, Fedorova M, Trumpp A, Conrad M, Friedmann Angeli JP. Nature. 2024 Jan 31. PMID: 38297129
- The ACE-inhibitor drug captopril inhibits ACN-1 to control dauer formation and aging. Egan BM, Pohl F, Anderson X, Williams SC, Adodo IG, Hunt P, Wang Z, Chiu CH, Scharf A, Mosley M, Kumar S, Schneider DL, Fujiwara H, Hsu FF, Kornfeld K. Development. 2024 Jan 29:dev.202146. PMID: 3828454
- DMHPpp1r17 neurons regulate aging and lifespan in mice through hypothalamic-adipose inter-tissue communication. Tokizane K, Brace CS, Imai SI. Cell Metab. 2024 Jan 1:S1550-4131(23)00462-X. PMID: 38194970