Congratulations to Dr. Aaron DiAntonio’s Lab on their recent publications!
Structural basis of SARM1 activation, substrate recognition, and inhibition by small molecules. Shi Y, Kerry PS, Nanson JD, Bosanac T, Sasaki Y, Krauss R, Saikot FK, Adams SE, Mosaiab T, Masic V, Mao X, Rose F, Vasquez E, Furrer M, Cunnea K, Brearley A, Gu W, Luo Z, Brillault L, Landsberg MJ, DiAntonio A, Kobe B, Milbrandt J, Hughes RO, Ve T. Mol Cell. 2022 May 5;82(9):1643-1659.e10.
Distinct developmental and degenerative functions of SARM1 require NAD+ hydrolase activity. Brace EJ, Essuman K, Mao X, Palucki J, Sasaki Y, Milbrandt J, DiAntonio A. PLoS Genet. 2022 Jun 23;18(6):e1010246.
Loss of Stathmin-2, a hallmark of TDP-43-associated ALS, causes motor neuropathy. Krus KL, Strickland A, Yamada Y, Devault L, Schmidt RE, Bloom AJ, Milbrandt J, DiAntonio A. Cell Rep. 2022 Jun 28;39(13):111001.